亚低温对重型颅脑伤患者血清细胞因子的影响  

Effect of mild hypothermia on serum cytokines levels in patients with severe brain injury

作　　者：秦宗和[1] 方玉明[1] 

机构地区：[1]上海交通大学医学院附属第三人民医院综合ICU,201900

出　　处：《中华创伤杂志》2006年第4期243-245,共3页Chinese Journal of Trauma

摘　　要：目的 探讨亚低温治疗对重型颅脑损伤患者血清中肿瘤坏死因子-α（TNF-α）、白细胞介素（IL）-1β、IL-6、IL-8的影响及临床意义。方法 选择符合条件的重型颅脑损伤患者[格拉斯哥昏迷评分（GCS）3～8分]共23例，于伤后24h内行亚低温治疗，控制直肠温度33～35℃，持续5d；对照组20例（GCS3～8分）。采用酶联免疫吸附法（ELISA）监测两组患者外周血清TNF-α、IL-1β、IL-6、IL-8在伤后第1，2，3，4天的动态变化。结果 亚低温治疗组患者血清TNF-α、IL-1β、IL-6、IL-8浓度较常规治疗组明显降低（P〈0．05）。结论 亚低温通过降低重型颅脑损伤患者血清中细胞因子的水平，减少了患者多器官功能障碍综合征的发生。Objective To explore the effect of mild hypothermia on tumor necrosis factor alpha （TNF-α） ,interleukin-1 β （ IL- 1 β）, interleukin-6 （IL-6） and interleukin-8 （ IL-8 ） in serum of patients with severe traumatic brain injury and its clinical significance. Methods Mild hypothermia was used within 24 hours after injury to keep the rectal temperature at 33℃-35℃ for five days in 23 patients, who suffered from severe brain injury with GCS score of 3-8 （ mild hypothermia group）. And 21 patients who suffered from severe brain injury with GCS score of 3-8 were taken as control group. The dynamic changes of serum TNF-α, IL-1 β, IL-6 and IL-8 at days 1,2, 3 and 4 respectively after trauma were monitored using ELISA. Results Levels of serum TNF-α, IL-1 β, IL-6 and IL-8 were decreased more significantly in the mild hypothermia group than those in the control group（P 〈 0.05）. Conclusion Mild hypothermia can decrease serum cytokines levels in patients with severe brain injury and hence reduce incidence of multiple organ dysfunction syndrome.

关 键 词：脑损伤 低温 人工 细胞因子 

分 类 号：R651.15[医药卫生—外科学] R563.1[医药卫生—临床医学]