控释氧氟沙星人工骨的质量控制及稳定性研究  

Study of quality Control and Stability of sustained release porous ofloxacin hydroxylapatite wax

作　　者：景利[1] 曾仁杰[1] 刘明蓉[1] 孙伟张[1] 青磊[1] 刘丰丰[1] 

机构地区：[1]成都军区总医院药剂科,贵阳医学院药学系

出　　处：《药学实践杂志》1996年第4期225-227,共3页Journal of Pharmaceutical Practice

摘　　要：本文对控释氧氟沙星人工骨（简称ＯＦＬＸ－ＰＨＡ－ｗａｘ）的质量控制及稳定性进行了初步探讨。实验表明，用紫外分光光度法测定ＯＦＬＸ－ＰＨＡ－ｗａｘ的含量时，辅料不干扰氧氟沙星的测定。用ＦＤＡ低温考查法、光照和加热稳定性试验考察了控释人工骨的稳定性。结果表明，其稳定性良好，使用期限可达２年以上。Preliminary study of quality control and stability of sustained release porous ofloxacin hydroxylapatite wax was made. Experimental results showed that necessities did not interfere with determination of ofloxacin by uv. Each stability showed that there were no effects of light, heat and humidity on ofloxacin-porous hydroxylapatite wax(OFLX-PHA-wax). The results showed OFLX-PHA-wax could keep stable within two years.

关 键 词：氧氟沙星 控释人工骨 质量控制 稳定性 

分 类 号：R978.19[医药卫生—药品] R318.17[医药卫生—药学]