月经、生殖因素与乳腺癌关系的病例对照研究  

A case-control study on the association of menstrual and reproductive factors with breast cancer

作　　者：翟祥军[1] 王水[2] 秦建伟[3] 王雪晨[4] 张亚男[5] 谈永飞[6] 周炎[6] 刘继永[1] 靳光付[1] 高君[1] 陈文森[1] 徐耀初[1] 沈洪兵[1] 

机构地区：[1]南京医科大学流行病与卫生统计学系,江苏南京210029 [2]南京医科大学第一附属医院普通外科,江苏南京210029 [3]江苏省肿瘤医院普通外科,江苏南京210009 [4]南京市鼓楼医院普通外科,江苏南京210009 [5]东南大学附属中大医院普通外科,江苏南京210009 [6]宜兴市人民医院,江苏宜兴214200

出　　处：《疾病控制杂志》2006年第2期109-113,共5页Chinese Journal of Disease Control and Prevention

摘　　要：目的分析评价江苏地区女性月经、生殖因素与乳腺癌发病风险的关系。方法采用病例对照研究,对经病理确诊的488例乳腺癌病例和482例对照进行月经、生殖因素与乳腺癌关系的单因素和多因素的logistic回归分析。结果单因素logistic回归分析结果显示,初潮年龄大、活产数多能降低乳腺癌的发病危险性;首胎活产年龄大患乳腺癌的危险性增加,有流产史和无母乳喂养史者患乳腺癌的危险性亦增加。多因素logistic回归分析结果与单因素分析结果较为一致。结论月经、生殖因素在江苏地区女性乳腺癌的发病过程中起重要作用。Objective To evaluate the association of menstrual and reproductive factors with breast cancer in Jiangsu province. Methods A case-control study and univariate and multivariate logistic regression were employed to evaluate the association of menstrual and reproductive factors with breast cancer in 488 breast cancer cases and 482 controls. Results Univariate logistic regression revealed that subjects with elder menarcheal age and more number of live births had lower risk of breast cancer, Subjects with elder age at first live birth and lack of breast-fed and having the history of abortion had higher risk of breast cancer. The results of multivariate logistic regression were similar to that of univariate logistic regression. Conclusions Menstrual and reproductive factors among women in Jiangsu province were associated with breast cancer.

关 键 词：乳腺肿瘤 病例对照研究 月经 生殖 LOGISTIC模型 

分 类 号：R339.2[医药卫生—人体生理学] R731.9[医药卫生—基础医学]