维生素E对大鼠肝、肾和脑组织过氧化脂质含量及谷胱甘肽过氧化物酶活性的影响  

Effect of vitamin E on the content of lipideperoxygen and the activity of glutathione peroxidase in liver,kidney and brain of rats

作　　者：宋祥福[1] 冯彪[1] 石贵山[1] 王柏[1] 

机构地区：[1]白求恩医科大学实验动物部

出　　处：《白求恩医科大学学报》1996年第3期232-234,共3页Journal of Norman Bethune University of Medical Science

摘　　要：本文探讨了维生素Ｅ（Ｖ＿Ｅ）对大鼠肝、肾和脑组织中过氧化脂质（ＬＰＯ）及谷胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ）活性的影响。结果表明，５．０×１０￣（－５），１．０×１０￣（－４），２．０×１０￣（－４），４．０×１０（－４），６．０×１０￣（－５）Ｖ＿Ｅ，各剂量组大鼠肝、肾中ＬＰＯ含量均低于对照组，而脑组织中仅２．０×１０￣（－４）和６．０×１０￣（－４）组与对照组间有差异。ＧＳＨ－Ｐｘ活性只有２．０×１０￣（－４）和４．０×１０￣（－４）组与相应对照组有差异。结果提示：Ｖ＿Ｅ有降低ＬＰＯ的作用，但Ｖ＿Ｅ所致的ＧＳＨ－Ｐｘ活性升高与ＬＰＯ降低有一致性的原因有待进一步研究。This report investigated the effect of vitamin E(VE)on the content of lipideperox-ygen (LPO) and the activity of glutathione peroxidase (GSH-Px)in the liver,kidney and brain ofrats.The result Showed that LPO contents of the different VE groups(5.0×10(-5),1.0×10(-4),2.0×10‘(-4),4.0×10(-4),6.0×10(-4))were all lower than those of control group in the liver and kidney ofrats,However there was difference only between 2.0×10(-4) and 6.0×10(-4) groups and control groupin the brain of rats. It indicated that VE might decrease LPO. But the reason that there was less uni-fomity between the activitv increase of GSH-Px and the content decrease of LPO needs to be stud-ied in the futre

关 键 词：维生素E 过氧化脂质 谷胱甘肽 过氧化物酶 肝 肾 

分 类 号：R977.25[医药卫生—药品]