新型铁碳复合磁性载体的制备及其物理生物学表征  

Preparation of noval magnetically targeted carriers of iron-carbon composite microparticles in tumor therapy and the comparision of their physical and biological property

作　　者：黄广建[1] 曹宏明[2] 武春涛[1] 甘军[1] 胡承恩[1] 吴秋芳[2] 於定华[2] 

机构地区：[1]复旦大学附属华山医院外科,上海200040 [2]华东理工大学国家超细粉末工程研究中心

出　　处：《中华实验外科杂志》2006年第4期545-547,共3页Chinese Journal of Experimental Surgery

基　　金：国家自然科学基金资助项目(30471682)国家科技部重大基础研究前期研究专项资助项目(2002CCA01100)

摘　　要：目的选择一种最佳铁碳复合磁性材料作为药物载体,用于肿瘤的磁靶向治疗。方法活性碳与纳米Fe3O4按9:1(Wt／Wt)球磨制成初级铁碳复合磁性材料,采用不同的表面包附技术及氢气还原制备出两种铁碳复合磁性载体,分别测定其粒子形貌与分布、磁性能、对阿霉素的吸附和脱附作用。结果合成的两种磁性载体为铁碳复合颗粒表面分别包附SiO2及碳,颗粒直径均小于500 nm;与包硅铁碳复合磁性载体相比,包碳铁碳复合磁性载体粒径较均匀(200-300)nm、磁饱和磁化强度较强(147 emu／g:89．9 emu／g)及最大载药量较高(每克载体吸附阿霉素233．8 mg: 163．2 mg)。结论包碳纳米铁碳复合磁性载体颗粒细小均匀、磁靶向性能强、载药量大并具有缓释功能,更适合作为磁性药物载体用于肿瘤的靶向治疗。Objective To select the best magnetic iron-carbon composite microparticles as a drug carrier in magnetically targeted therapy of tumor. Methods Activated carbon and nanometeric Fe3O4 was mixed and milled at the proportion of 9 ： 1 （wt/wt） to form primary iron-carbon composite particles. Two magnetical iron-carbon composite microparticles were synthesized with hydric deoxidation and different surface encapsulated techniques. Their morphology, magnetic property, the adsorbable or desorbable ability to doxorubicin were determined respectively. Results Both magnetic carriers were made of iron-carbon composite microparticles which were less than 500 nm in diameter and encapsulated with SiP2 and carbon respectively. Iron-carbon composite microparticles coated with carbon had more uniform size （Ф200-300 nm）, more powerful saturation magnetization intensity （147 emu/g： 89.9 emu/g） and higher maximum adriamycin-absorbed content （233.8 mg/g： 163.2 mg/g） than iron-carbon composite microparticles coated with SiO2. Conclusion Iron-carbon microparticles coated with carbon are the promosing magnetical carriers in targeted therapy of tumor as the drug carrier having tiny and uniform size, more powerful saturation magnetization, higher content of drug-carrying and more effective slow-releasing property than iron-carbon composite microparticles coated with SiO2.

关 键 词：磁性载体 肿瘤 阿霉索 纳米 

分 类 号：R318.08[医药卫生—生物医学工程]