长春新碱透皮给药系统筛选及其透皮机理研究  

Selection of transdermal vincristrine and research on drug delivery system for the transdermal mechanism

作　　者：卢懿[1] 侯世祥[1] 姚倩[1] 张瑜[1] 花英志[1] 张喆[1] 

机构地区：[1]四川大学华西药学院,成都610041

出　　处：《高技术通讯》2006年第3期271-274,共4页Chinese High Technology Letters

基　　金：国家自然科学基金（30472194）资助项目.

摘　　要：分别制备了含不同表面活性剂的载长春新碱传递体（VCR-T）和载长春新碱壳聚糖纳米粒（VCR-CS-NPs），通过体外透皮试验，比较了不同透皮给药系统的透皮效果，并用DSC扫描探索了透皮效果差异的原因。所制备的VCR—T包封率从50％至80％不等，粒径90nm左右；VCR-CS-NPs的包封率为50％，粒径200nm左右；透射电镜下观察VCR—T和VCR-CS—NPs均外形圆整光滑，不粘连。体外透皮结果显示含Brij78的VCR-T为最佳的VCR透皮给药系统，DSC扫描认为这与载体与Brij78的相互作用有关；VCR-CS-NPs不能很好地透过皮肤，这可能与其粒径较大有关。Vincristine loaded transfersomes （VCR-T） containing different surfactants and vincristine loaded chitosan-nanoparticles （VCR-CS-NPs） were prepared respectively. And their transdennal effects were compared through transdermal experiment in vitro. Besides, DSC was used to study factors affecting the transdermal effects. The entrapment efficiency of VCR-T varied from 50% - 80% with an average diameter of 90 nm. And the entrapment efficiency of VCR-CS-NPs was 50% with an average diameter of 200 nm. Both of the carriers were spherical and smooth under transmission electron microscope. The results of transdermal experiment in vitro showed that VCR-T containing Brij78 was the best transdermal drug delivery system for vincristine, which concerns with the interaction between Brij78 and cartier based on the proof of DSC scan. In contrast, VCR-CS-NPs could not penetrate skin efficiently, which probably has something to do with the larger particle sizes.

关 键 词：长春新碱 表面活性剂 传递体 壳聚糖纳米粒 透皮给药 

分 类 号：TQ460.4[化学工程—制药化工] Q55[生物学—生物化学]