无症状心肌缺血和心绞痛患者血浆中内皮素、降钙素基因相关肽和P物质含量的变化  

Change of plasma endothelin(ET),calcitonin generelated peptide(CGRP)and substance P levels between patientswith painless or with painful myocardial ischemia

作　　者：李大元[1] 张钧华[1] 童琳[1] 邵耕[1] 丁文惠[1] 林静[1] 

机构地区：[1]北京医科大学第一医院心内科

出　　处：《中国病理生理杂志》1996年第4期396-398,共3页Chinese Journal of Pathophysiology

摘　　要：本文测定了无症状心肌缺血（ＳＭＩ）组（１４例）、心绞痛组（１１例）和对照组（７例）运动试验前后血浆内皮素（ＥＴ）、降钙素基因相关肽（ＣＧＲＰ）和Ｐ物质（ＳＰ）的含量，探讨了这３种肽类物质在ＳＭＩ和心绞痛发生中作用的差异。结果显示：运动前３组之间血浆ＥＴ含量比较无显著性差异，运动后３组组血浆ＥＴ含量分别为７７．７０±１８．４４，１１１．３３±２４．８２，９４．３８±１２．５９ｎｇ／Ｌ心绞痛组显著高于ＳＭＩ组（Ｐ＜０．０１）．运动前３组之间和运动后３组之间血浆ＣＧＲＰ含量比较均无显著性差异。运动前３组之间血浆ＳＰ含量比较无显著性差异，运动后３组血浆ＳＰ含量分别为２．２５±０．２１、２．４６±０．２０、２．１８±０．１２ｎｍｏｌ／Ｌ，心绞痛组明显高于ＳＭＩ组（Ｐ＜０．０５）和对照组（Ｐ＜０．０１）．结果提示：血浆ＥＴ、ＳＰ含量升高可能参与了心绞痛的发生，而心肌缺血时无症状可能与血浆ＥＴ、ＳＰ未升高有关。This work was designed to measure the changes of plasma ET,CGRP andsubstance P levels in painless and painful patients so as to study the pathogenesis ofpainless myocardial ischemia. In 15 painless patients(group 1),11 painful patients(group2)and 7 healthy controls(group 3),the plasma levels of ET,CGRP and substanee P weremeasured by radio immuno assay at resting state and immediately after exercise test.Nostatistical differences in all resting plasma ET,CGRP and substanee P levels among thethree groups were found.The plasma CGRP Ievel among the three groups wasn’tsignificantly different after exercise. However,after exercise,the plasma levels of ET ingroups 1,2,3 were 77.70 ± 18.44,111.33 ±24.82,94.38 ± 12.59ng/L,respectively,while theplasma levels of substanee P in groups 1,2, 3 were 2.25 ± 0.21,2.46±0.20,2.18±0.1 6nmol/L,respectively.Both the plasma levels of ET and substanee P in group 2was significantly higher than those in groups 1 and 3(P<0.0 1 and P < 0.05, respectively). This results suggested that painful myocardial ischemia may be related to the increaseof plasma levels of ET and substance P, while in painless myocardial ischemia plasma levelsof ET and substanee P were not changed.

关 键 词：心肌缺血 P物质 心绞痛 内皮素 降钙素 

分 类 号：R541.502[医药卫生—心血管疾病]