花椒毒酚抗实验性心律失常作用的研究  

Studies on the Anti-arrhythmic Effect of Xanthotoxol in Experimental Animals

作　　者：连其深[1] 张志祖[1] 上官珠[1] 周俐[1] 皮荣标[1] 向仁德[2] 韩英[2] 张新勇[2] 

机构地区：[1]赣南医学院药理教研室,赣州341000 [2]南京药物研究所

出　　处：《中草药》1996年第6期347-349,共3页Chinese Traditional and Herbal Drugs

基　　金：卫生部拨款资助

摘　　要：花椒毒酚（xanthotoxol，XT）是从蛇床子乙醇提取物中分离出的一种香豆素。XT对氯仿诱发的小鼠室颤、氯化钙诱发的大鼠室颤均有明显的预防作用，对乌头碱诱发的大鼠心律失常有明显的治疗效果，且能明显提高兔心室电致颤阈。此外，XT还能降低蟾蜍离体坐骨神经干的动作电位振幅。表明XT有抗心律失常的作用。XT的小鼠ivLD50为47．0mg／kg。　Xanthotoxol (XT) is a coumarin isolated from ethanolic extract of fruits of Cnidium monnieri (L. )Cus　son. It is effective not only for the prevention of ventricular fibrillation of mice induced by chloroform or that of rats induced by calcium chloride,but also is effective for the treatment of arrhythmia induced by aconitine in rats. It can raise the threshold of ventricular fibrillation induced by electrical stimulation in rabbits. Fur　thermore,XT can inhibit the action potential amplitude of isolated sciatic nerves in toads. These results indi　cated that XT possesses antiarrhythmic effects. The iv LD50 of XT in mice is 47.0mg/kg

关 键 词：花椒毒酚 药理 抗心律失常 

分 类 号：R259.417[医药卫生—中西医结合] R282.710.5[医药卫生—中医内科学]