免疫复合物与家兔胆色素结石成因研究  

Experimental Study on Immune-complex and the Mechanism of Bile Pigment Stone For-mation in rabbits

作　　者：冉崇福[1] 杨可桢[2] 韩本立[2] 段恒春[2] 别平[2] 

机构地区：[1]解放军452医院普外科,成都610061 [2]第三军医大学西南医院肝胆外科中心

出　　处：《中华实验外科杂志》1996年第4期223-224,共2页Chinese Journal of Experimental Surgery

摘　　要：以胆色素结石(PS)动物模型为基础选用家兔40只,随机分4组,每组10只。观察不同组别成石率;胆汁、血清中免疫复合物(IC)、特异性IgG含量;以及各组成石率与其胆汁血清中IC、IgG含量的相关性。结果表明,死菌活菌组都有很高的成石率,而^(60)Co照射组成石率显著降低,各组成石率与其胆汁血清中IC、IgG含量呈非常显著正相关。因此,IC形成及其抗原抗体亲和力等免疫学机制可能是PS形成的重要原因之一。An animal model of bile pigmental stone(PS) formation was made in 40 rabbits. They were divided into 4 groups with each group having 10 rabbits. The rate of PS formation in various groups, immune-complex (IC), specific IgG in the bile and serum were examined. The results show that: 1)There was a very high rate of PS in both injected live and dead 3360 E. coli Ag groups, however, the rate of PS in the ^(60)Co irradiated group was much lower than that in above two groups; (2) There was a close relationship in each group between the rate of PS and IC, IgG in serum or bile. It is eoncluded that the formation of IC and the affinity of Ag-Ab might facilitate the PS formation.

关 键 词：免疫复合物 胆色 胆结石 病因 

分 类 号：R657.420.2[医药卫生—外科学]