老年急性冠脉综合征患者血清可溶性Fas变化及意义  

Serum levels of soluble Fas in elderly patients with acute coronary syndrome

作　　者：胡司淦[1] 蔡鑫[1] 高大胜[1] 张恒[1] 史晓俊[1] 王洪巨[1] 

机构地区：[1]蚌埠医学院附属医院心血管科,安徽省蚌埠市233004

出　　处：《实用老年医学》2006年第2期113-115,共3页Practical Geriatrics

摘　　要：目的探讨老年急性冠脉综合征(ACS)患者血清中可溶性Fas(sFas)的变化及意义。方法应用酶联免疫吸附双抗体夹心(ABC-ELISA)法,测定40例老年ACS患者[包括14例不稳定型心绞痛(UAP)、26例急性心肌梗死(AMI)]和17例对照组受试者血清sFas的水平,其中ACS患者同时应用该方法进行血清肌钙蛋白I(cTnI)定量检测。结果AMI组和UAP组血清sFas水平均明显高于对照组(P<0.05),ACS患者中cTnI升高组与正常组血清sFas水平差异无显著性(P>0.05)。结论高水平的血清sFas可能与ACS有关,血清sFas水平的变化早于cTnI的变化,可作为判断动脉粥样硬化斑块稳定性的指标。Objective To explore the variation and clinical significance of serum levels of soluble Fas （sFas） in elderly patients with acute coronary syndrome （ACS）. Methods By enzyme-linked immunosorbent assay （ELISA） , serum sFas was measured in 40 elderly patients with ACS [ including 14 unstable angina peetoris （UAP） and 26 acute coronary myocardial infarction （AMI） ] and 17 subjects without coronary heart disease. Forty patients with ACS underwent the measurement of cardiac tropnin I （eTnI）. Results Mean level of sFas was significantly higher in patients with AMI than that in controls （P 〈 0. 05 ）. Mean level of sFas was also significantly higher in patients with UAP than that in controls（ P 〈 0. 05）. No difference was found in patients with ACS with increased cTnI or without （P 〉0.05）. Conclusions High serum levels of sFas may have relationship with ACS. The serum level of sFas changed before the variation of cTnI. Therefore,it may be an efficient index to predict the stability of atherosclerotic plaque.

关 键 词：冠状动脉疾病:肌钙蛋白I:老年人 

分 类 号：R541[医药卫生—心血管疾病]