清热理气冲剂对大鼠实验性胆汁反流性胃炎的治疗作用  

Mechanism of action of Qingre Liqi granules for the treatment of experimental bile reflux gastritis in rats

作　　者：韩俊岭[1] 姚树坤[1] 殷飞[1] 

机构地区：[1]河北医科大学第四医院,河北石家庄050011

出　　处：《中国医院药学杂志》2006年第4期388-390,共3页Chinese Journal of Hospital Pharmacy

摘　　要：目的:探讨清热理气冲剂治疗胆汁反流性胃炎的作用机制。方法:60只大鼠随机分为6组,除去正常对照组,其余各组大鼠应用胆汁灌胃导致胃黏膜损害。2周后分别应用清热理气冲剂等效剂量、大剂量、西沙必利、枸橼酸铋钾处理。观察胃黏膜病理形态和超微结构变化,应用放射免疫法测定胃黏膜瘦素、前列腺素E2、内皮素和白细胞介素-8的含量。结果:中药等效剂量组和大剂量组胃黏膜病理形态和超微结构较之病理对照组显著改善。与病理对照组比较,胃黏膜瘦素和前列腺素E2含量明显增高,而血浆内皮素和血清白细胞介素-8含量明显降低。结论:清热理气冲剂可以减轻胃黏膜损伤治疗胆汁反流性胃炎。OBJECTIVE To investigate the mechanism of action of Qingre Liqi granules in treating bile reflux gastritis. METHODS Sixty rats were randomly divided into six groups. Gastric mucosal injury of rats was induced with bile poured into stomach except normal control group. Two weeks later the groups were dealt with small-dose, large-dose Qingre Liqi Granules, eisapride, colloidal bismuth subcitrate respectively. The pathomorphology and ultrastructure of gastric mucosa were observed and the levels of leptin, PGE2, ET and IL-8 were measured by radioimmunoassay. RESULTS Compared with model control group, the lesions of pathomorphology and ultrastructure of gastric mucosa in small dose and large-dose Qingre Liqi granules groups were obviously improved. The levels of gastric mucosa leptin and PGE2, in small-dose and large-dose Oingre Liqi granules groups were higher than in model control group. The levels of plasma ET and serum IL-8 in small-dose and large-dose Qingre Liqi granules groups were lower than in model control group. CONCLUSION Qingre Liqi granules can relieve injury of gastric mucosa and treat bile reflux gastritis through affecting the levels of gas.tric mucosa leptin, PGE2, plasma ET and serum ILS.

关 键 词：清热理气冲剂 胆汁反流性胃炎 瘦素 前列腺素E2 内皮素 白细胞介素-8 

分 类 号：R965[医药卫生—药理学]