脱叶灵的合成工艺研究  

Synthesis Method of Thidiazuron

作　　者：陈同明[1] 赵卫东[1] 邢华[1] 

机构地区：[1]江苏安邦电化有限公司,江苏淮安223002

出　　处：《现代农药》2006年第2期17-18,26,共3页MODERN AGROCHEMICALS

基　　金：江苏省星火计划攻关项目(B类:033208000040)

摘　　要：以碳酸二甲酯、水合肼和氯乙醛等为原料,经过三步反应,制得关键中间体5-氨基-1,2,3-噻二唑,再与苯基异氰酸酯反应,合成了脱叶灵。通过实验研究,筛选了适合的溶剂和优化的反应条件,使产品总收率提高到18%,产品含量达到96%。本方法反应条件温和,三废减少,更适合于工业化生产。In this article, three materials including dimethyl carbanate, hydrazine hydrate and chloroacetaldehyde were reacted into key intermediate 5-amino-1,2,3-thiadiazole. It reacted with phenyl isocyanate to get thidiazuron. From this test, suitable solvent and optimal reaction conditions were found, Under such conditions the yield reached 18% and purity of product 96%. The process enjoys advantages of mild reaction conditions, less waste and easier industrialization.

关 键 词：脱叶灵 合成 中间体 反应条件 

分 类 号：TQ452.4[化学工程—农药化工]