茚酮肟醚衍生物的合成与生物活性  

Synthesis and Biological Activity of Oxime Ethers Containing Indanone

作　　者：凌立志[1] 柳爱平[2] 陈灿[2] 魏振中[2] 王胜得[2] 尹笃林[1] 王晓光[2] 

机构地区：[1]湖南师范大学化学化工学院,湖南长沙410081 [2]湖南化工研究院国家南方农药创制中心湖南基地,湖南长沙410007

出　　处：《农药学学报》2006年第1期25-29,共5页Chinese Journal of Pesticide Science

基　　金：国家"十五"科技攻关重点项目(2004BA308A22-1);国家自然科学基金项目(20037202120572019);湖南省自然科学基金重点项目(No.01JJY1001)

摘　　要：通过傅-克反应及环化、肟化、成醚等反应,合成了10个未见文献报道的茚酮肟醚类化合物,其结构均经1H NMR、IR、LC/M S及元素分析确证。初步生物活性测试结果表明,所合成的化合物具有明显的杀菌活性或杀虫活性,如在100mg/L时,化合物V1对小麦白粉病菌E rysiphegram inis的抑制率为95.6%,V5对粘虫M ythimna separata的致死率为100%。Ten oxime ethers containing indanone were synthesized by Friedel-Crafts reaction, cyclization, oximation, etherification. All novel compounds were confirmed by I H NMR, IR, LC/MS and elemental analysis. The preliminary bioassay results showed that some compounds had obviously fungicidal or insecticidal activities, for example, the inhibitory ratio of compound V1 against Erysiphe Graminis was 95.6%, while the fatal ratio of compound Vs against Mythimna separate was 100% at the concentration of 100 mg/L.

关 键 词：茚酮肟醚 合成 杀虫活性 杀菌活性 

分 类 号：O623.542[理学—有机化学]