部队人群肺结核发病因素的病例对照研究  

Case control study on the risk factors for pulmonary tuberculosis in servicemen of China

作　　者：刘玮[1] 张芳[1] 赵秋敏[1] 吴晓明[1] 张翠英[2] 田磊[3] 李春芝 张泮河[1] 杨红[1] 曹务春[1] 

机构地区：[1]军事医学科学院微生物流行病研究所 [2]解放军第309医院,北京100091 [3]解放军第91医院,山东兖州272100 [4]解放军总参三部防疫队,北京100091

出　　处：《中国热带医学》2006年第4期569-571,共3页China Tropical Medicine

基　　金：国家自然科学基金(30271144)

摘　　要：目的研究部队人员肺结核发病的危险因素。方法采用病例对照研究设计，通过问卷调查获得相关环境因素的信息，采用SPSS软件进行非条件单因素Logistic回归分析，计算OR值及95％CI。结果共152名病例和259名对照纳入分析，单因素分析发现卡介苗接种史及与结核病人密切接触史在病例和对照组中的分布有显著性差异，前者是肺结核发病的保护因素，OR值（95％CI）为0．44（0．29-0．68），后者是肺结核发病的危险因素，OR值（95％CI）为2．12（1．04～4．32）。而抽烟、饮酒情况、肉类摄入量、蔬菜摄入量、健身状况等其他因素在两组中分布差异无显著性。结论卡介苗接种对部队人员结核病发生有显著保护作用，而肺结核病例接触史是一个潜在的危险因素。Objective To investigate the risk factors associated with pulmonary tuberculosis （P. tb） in the Chinese servicemen. Methods Case control study was carried out and a standard questionnaire survey was performed to collect the disease associated information. Data were analyzed using SPSS software, Unconditional logistic regression was performed to examine the effect of each variable separatcly. Results A total of 152 cases and 259 controls were included in the study. Exposure history and Baeille Calmette Guérin （BCG） immunization were statistically significant, with OR （95%CI） to be 0.44（0.29 - 0.68）and 2.12（1.04 - 4.32）, respeetively. No significant difference was observed for other factors, including tobacco use, alcohol intake, nutrition status and physical aetivily. Conclusion It is suggested that exposure history is a potential risk factor for P. tb, while BCG immunization might be associated with the protection from the disease in the Chinese servicemen.

关 键 词：肺结核 病例对照研究 卡介苗 

分 类 号：R521[医药卫生—内科学]