“温通针法”对拟血管性痴呆模型大鼠血浆TXB_2、6-keto-PGF_(1α)的含量影响  

Effects of Wentong acupuncture method on the contents of TXB_2 and 6-keto-PGF_(1α) in the serum of model rats with vascular dementia

作　　者：刘恩远[1] 马蕾[1] 郑魁山（指导） 

机构地区：[1]甘肃中医学院,甘肃兰州730000 [2]不详

出　　处：《甘肃中医学院学报》2006年第2期17-19,共3页Journal of Gansu College of Traditional Chinese Medicine

摘　　要：目的:探讨“温通针法”治疗血管性痴呆(VD)的机理,为进一步推广本疗法奠定基础。方法:将60只W istar大鼠随机分为假手术组、模型对照组、捻转针法组、温通针法组、药物组,采用反复夹闭双侧颈总动脉—再灌注造成血管性痴呆大鼠模型,并行相应处理。各组大鼠经过治疗,跳台实验结束后,利用放射免疫学方法检测大鼠血浆中血栓素B2(TXB2)及6-酮-前列腺素F1α(6-Keto-PGF1α)含量。结果:“温通针法”能使VD大鼠血浆中6-Keto-PGF1α含量显著升高,TXB2含量显著下降。结论:“温通针法”通过调整VD大鼠血浆中TXB2、6-Keto-PGF1α之间的平衡,增加VD大鼠脑血流量,改善脑功能。这可能是“温通针法”治疗VD取效的主要机制之一。Objective： To explore the mechanism of Wentong acupuncture method on treating vascular dementia（VD） ,thereby lay a foundation to further spread the divided into negative injury group, model control group, therapy. Methods：60 Wistar rats were randomly twirling needle method group, Wentong acupuncture method group and medicine group. The VD models of were sion of bilateral common carotid artery, and the relevant established by repeated cerebral ischemia-reperfuhandling was done. The contents of TXB2 and 6-Keto- PGF1α in the plasma were examined with radio-immunity method after treating and step-down avoidance test. Results： Wentong acupuncture method could significantly improve the content of 6-Keto-PGF1α in the plasma and reduce the content of TXB2. Conclusion：Wentong acupuncture method can improve the volume of blood flow in brain of rats with VD and function of by adjust the balance of TXB2 and 6-Keto-PGF1α. It is possibly one of the main mechanisms of Wentong acupuncture method on treating VD.

关 键 词：“温通针法” 血管性痴呆 血栓素B2 6-酮-前列腺素F1Α 

分 类 号：R285.5[医药卫生—中药学]