+Gz暴露对大鼠大脑皮层HSP70蛋白表达的影响  

Effect of +Gz exposures on the expression of HSP70 protein in rat cortex

作　　者：韩磊[1] 李鸣皋[1] 马贵喜[1] 孙喜庆[2] 

机构地区：[1]解放军海军总医院航空潜水医学中心,北京100037 [2]第四军医大学航空航天医学系航空生物动力学教研室

出　　处：《西北国防医学杂志》2006年第2期85-86,F0003,共3页Medical Journal of National Defending Forces in Northwest China

基　　金：国家自然科学基金资助项目(39800158)

摘　　要：目的:观察+G z暴露对大鼠大脑皮层HSP70蛋白表达水平的影响,探讨+G z暴露致脑损伤的机理。方法:100只SD大鼠随机分为对照组,+2 G z暴露组,+6 G z暴露组,+10 G z暴露组,各组在G暴露后的6 h、1、2、4、6 d处死,免疫组织化学方法观察大鼠脑皮层HSP70蛋白表达情况,并对结果进行统计分析。结果:3个+G z暴露组的HSP70蛋白表达水平均显著高于对照组;不同G值之间的比较表明,+6 G z组HSP70蛋白表达水平最高,+10 G z组最低。结论:+G z暴露对大鼠大脑皮层HSP70蛋白表达水平有显著影响。Objective： To observe the changes of expression level of HSP70 protein in rat cortex after exposure to ＋Gz and investigate the mechanism of brain injury induced by ＋Gz exposure. Methods： A total of 100 rats were divided into 4 groups： control group, ＋2Gz group, ＋6Gz group and ＋10Gz group. The rats were killed at 6h, 1d, 2d, 4d and 6d after exposure and the changes of HSP70 protein expression level were measured With immunohistochemical technology. Results： The HSP70 protein expression level of ＋Gz exposure groups were significantly higher than that of control group. The highest expression level was in ＋6Gz group and the lowest was in ＋10Gz group. Conclusion： Effect of ＋Gz exposures on the expression of HSP70 protein in rat cortex is significant.

关 键 词：HSP70蛋白 +GZ暴露 大鼠 

分 类 号：Q426[生物学—神经生物学]