钙拮抗剂对脊髓损伤所致逼尿肌不稳定模型下离体逼尿肌的功能影响  

Effect of calcium antagonist on functions of isolated detrusor strip in rats following spinal cord injury

作　　者：张武合[1] 宋波[1] 方强[1] 金锡御[1] 胡利发[2] 

机构地区：[1]第三军医大学西南医院全军泌尿中心,重庆400038 [2]解放军第323医院泌尿外科

出　　处：《西北国防医学杂志》2006年第2期87-89,共3页Medical Journal of National Defending Forces in Northwest China

基　　金：国家自然科学基金资助项目(30371429)

摘　　要：目的:探讨钙拮抗剂对脊髓损伤引起的不稳定逼尿肌的兴奋性、收缩性的影响。方法:建立大鼠脊髓损伤动物模型,6周后行充盈性膀胱测压及离体逼尿肌条机械牵拉、钙拮抗剂刺激试验。结果:脊髓损伤后逼尿肌不稳定的发生率为100%;模型组与对照组相比,自律性和收缩性明显升高,收缩力增强;在L型、T型钙通道阻滞剂作用下,两组自律性、收缩力均明显降低,其中正常组更明显(P<0.05)。结论:逼尿肌不稳定的发生与其自身兴奋性增高密切相关,而钙通道数量表达和功能改变可能是逼尿肌兴奋性增高的重要原因。Objective： To investigate the influence of calcium antagonist on detrusor excitability and contractility, and elucidate the pathogenesis of detrusor instability （DI） caused by spinal cord injury （SCI）. Methods： Animal models of SCI were made in female SD rats. Six weeks later, the change of detrusor excitability and contractility were examined by means of cystometry and in vitro detmsor strip study. Results： The incidence rate of DI was 100%. Both Nifedipine and NiCl2 decreased the range and the frequency of the spontaneous contraction of detrusor strip in the DI group and the control group, the latter was more significantly （P 〈 0.05）. Conclusion： The mechanismof DI is closely related to the increase of spontaneous excitability of detrusor muscle, while the changes in function and quantity of calcium channels seem to be more important to the excitability.

关 键 词：逼尿肌不稳定 脊髓损伤 钙拈抗剂 

分 类 号：R651.2[医药卫生—外科学] R694[医药卫生—临床医学]