两亲性三嵌段共聚物PAA-PHB-PAA的合成及表征  

Synthesis and Characterization of Amphiphilic Triblock Copolymers PAA-PHB-PAA

作　　者：张雪勤[1] 郑云[1] 杨琥[1] 刘全伟[1] 谢鸿峰[1] 王治流[1] 程镕时[1] 

机构地区：[1]南京大学化学化工学院介观化学教育部重点实验室高分子科学与工程系,南京210093

出　　处：《高等学校化学学报》2006年第4期784-786,共3页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:20204004;20474026);教育部博士学科点基金(批准号:20030284003)资助

摘　　要：A new biodegradable PtBA-PHB-PtBA triblock copolymer was successfully synthesized by ATRP method with Br-PHB-Br as macroinitiator,tert-butyl acrylate as monomer and CuBr/PMDETA as the catalyst system.Cleavage of the tert-butyl ether groups of the PtBA-PHB-PtBA triblock copolymer was then performed via hydrolysis with trifluoroacetic acid as the catalyst in dichloromethane to afford the amphiphilic PAA-PHB-PAA triblock copolymer.The hydrolysis is successful but trace tert-butyl ether groups still remain in the backbone.The molecular weight characteristics and chain structures were conformed by GPC and NMR,respectively.Because of hydrophilic and biocompatibility,the amphiphilic triblock copolymers have potential applications in the field of drug release.A new biodegradable PtBA-PHB-PtBA triblock copolymer was successfully synthesized by ATRP method with Br-PHB-Br as macroinitiator, ten-butyl acrylate as monomer and CuBr/PMDETA as the catalyst system. Cleavage of the tert-butyl ether groups of the PtBA-PHB-PtBA triblock copolymer was then performed via hydrolysis with trifluoroacetic acid as the catalyst in dichloromethane to afford the amphiphilic PAA-PHB-PAA triblock copolymer. The hydrolysis is successful but trace ten-butyl ether groups still remain in the backbone. The molecular weight characteristics and chain structures were conformed by GPC and NMR, respectively. Because of hydrophilic and biocompatibility, the amphiphilic triblock copolymers have potential applications in the field of drug release.

关 键 词：原子转移自由基聚合(ATRP) 两亲性三嵌段共聚物 合成 表征 

分 类 号：O631[理学—高分子化学]