去质子化调控的肝素/壳聚糖抗凝血多层膜  

Deionized Mediated Anticoagulant Heparin/Chitosan Multilayer Films

作　　者：谭庆刚[1] 林全愧[1] 范德增[2] 计剑[1] 沈家骢[1] 

机构地区：[1]浙江大学高分子科学与工程学系 [2]北京钢铁研究总院,北京100081

出　　处：《高等学校化学学报》2006年第4期787-789,共3页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:50373036);教育部霍英东基金优选项目(批准号:J20040212)资助

摘　　要：The influence of different pH values between assembly and application environment on the surface properties of layer-by-layer assembled heparin and chitosan multilayer films was investigated.The high adsorption amount of cationic dye and high wettability on the chitosan terminated multilayer films at high environment pH may indicate the excess of free sulfate group existed on the chitosan surface.Since the ionization degree of chitosan decreased with increasing of pH,the multilayer films assembled at low pH will lead to some excess free unpaired sulfate group in higher pH application environment,which paired with ionized amino group under prepared conditions.The blood-compatibility tests performed with these films clearly demonstrated that the good anticoagulant activity of low pH assembled heparin/chitosan even on the chitosan-terminated surface.Such an easy and controlled processing by the difference of pH values between assembly and application environment may have a good potential for fabrication of biomedical device coating.The influence of different pH values between assembly and application environment on the surface properties of layer-by-layer assembled heparin and chitosan multilayer films was investigated. The high adsorption amount of cationic dye and high wettability on the chitosan terminated multilayer films at high environment pH may indicate the excess of free sulfate group existed on the chitosan surface. Since the ionization degree of chitosan decreased with increasing of pH, the muhilayer films assembled at low pH will lead to some excess free unpaired der p good sulfate group in higher pH application environment, which paired with ionized amino group unrepared conditions. The blood-compatibility tests performed with these films clearly demonstrated that the anticoagulant activity of low pH assembled heparin/chitosan even on the chitosan-terminated surface. Such an easy and controlled processing by the difference of pH values between assembly and application environment may have a good potential for fabrication of biomedical device coating.

关 键 词：层层自组装膜 抗凝血 去质子化 

分 类 号：O631.3[理学—高分子化学]