小剂量rt-PA快速给药30min与60min治疗急性心肌梗死疗效观察  

Curative effects of rapid administration of low dose rt-PA for 30 minutes and 60 minutes on acute myocardial infarction

作　　者：李十红[1] 李志忠[1] 朱小玲[1] 高海[1] 李楠[1] 艾辉[1] 杜如跃[1] 

机构地区：[1]首都医科大学附属北京安贞医院心肺血管疾病抢救中心,北京100029

出　　处：《中华急诊医学杂志》2006年第4期345-347,共3页Chinese Journal of Emergency Medicine

基　　金：国家973攻关项目(2003CB517103)

摘　　要：目的旨在为临床在应用rtPA溶栓方面找到一个更好更安全的方案。方法通过比较小剂量50mgrtPA30min与60min快速给药治疗急性ST段抬高性心肌梗死患者的效果89例,随机分为两组:rtPA30min给药和60min给药,比较两组患者临床疗效、冠脉再通率、心脏事件发生率、并发症以及急性期病死率。结果30min给药组再通率高达84.7%,与60min给药组比较患者临床症状改善和冠状动脉再通率均差异有显著性,梗死后心绞痛、再灌流心律失常发生率明显降低,出血并发症没有增加(P<0.05)。结论小剂量rtPA30min治疗AMI是安全可靠有应用价值值得推广的方法。Objective To find a safe and effective way to use rt-PA in treating acute mycardiad infarction （AMI）. Methods Eighty-nine acute myocardial infarction patients with ST segment elevation, were divided into two groups at random. Curative effect, coronary recanalization, incidence rate of cardiac events, complications, mortality at acute stage after given 50 mg rt-PA in 30 min and in 60 min were compared. Result Compared with group 50 mg rt-PA in 60 rain, symptom improvement and incidence rate of coronary recanallztion in group given 50 mg rt-PA 30 min were significantly different, and coronary recanalization rate reached 84.7%. Incidence rate of angina pectoris after MI and recanalization arrhythmia were markedly reduced （ P 〈 0.05）. Conclusion Given low dose of rt-PA within 30 min is effective and safe in treating AMI.

关 键 词：急性心肌梗死 静脉溶栓 重组组织型纤维酶原激活物剂 

分 类 号：R542.22[医药卫生—心血管疾病]