深圳市宝安区结核分枝杆菌耐药性监测分析  

STUDY ON DRUG RESISTANCE OF MYCOBACTERIUM TUBERCULOSIS IN BAOAN DISTRICT.

作　　者：黄宝珍[1] 邱永忠[1] 肖锦晖[1] 彭石潜[1] 温贵华[1] 

机构地区：[1]深圳市宝安区慢性病防治院,深圳518133

出　　处：《现代预防医学》2006年第4期538-538,542,共2页Modern Preventive Medicine

摘　　要：目的:监测宝安辖区结核分支杆菌(MTb)耐药性,确定本地区MTb的耐药水平。方法:对2002年至2004年宝安辖区连续3年的结核病人痰培养结核分支杆菌阳性株随机抽样,采用绝对浓度法,对这些菌株进行异烟肼(INH)、链霉素(SM)、利福平(RFP)、乙胺丁醇(EMB)、氧氟沙星(OFL)的耐药测试,并接种不含药的培养基作为对照,接种对硝基苯甲酸培养基(PNB)、噻吩-2-羧酸肼培养基(TCH)进行菌种鉴别。结果:2002年总耐药率79·53%,耐多药31·5%。2003年总耐药率76·47%,耐多药27·94%。2004年总耐药率71·75%,耐多药25·95%。结论:宝安辖区结核分支杆菌的耐药率及耐多药率处于较高水平,但呈缓慢下降的趋势。Objective： To investigate the local status of drug resistance of mycobacterium tuberculosis （MTb）, and to analyse its trend. Methods： From 2002 to 2004, 394 cases of pulmonary tuberculosis with culture positive from Baoan district were enrolled in the study. Identification （inoculated in PNB and TCH） and susceptibility （absolute concentration method for INH , SM, RFP, EMBandOFL ） tests were done in all cases. And control group （inoculated in culture medium without any drug） was sel up.Results： 79.53% MTb had drug resistance and the multi- drug resistance rate was 31.5% in 2002. 76.4% MTb had drug resistance and the multi - drug resistance rate was 27.94 % in 2003. 71.75 % MTb had drug resistance and the multi - drug resistance rate was 25.95 % in 2004.Conclusion： Local drug resistance rate of MTb is higher than the average level of the whole country. And it might decline slowly.

关 键 词：结核分支杆菌 药物耐受性 监测 

分 类 号：R52[医药卫生—内科学]