哮喘患儿血清IL-18、IL-4和INF-γ水平测定的临床意义的研究  

Study on the clinical significance of serum IL-18,IL-4 and INF-γ levels in children with asthma

作　　者：肖春香[1] 殷小成[1] 尹珊辉[1] 匡艳华[2] 王金兰[1] 

机构地区：[1]南华大学第一附属医院小儿科,湖南省衡阳市421001 [2]南华大学第一附属医院检验科

出　　处：《实用诊断与治疗杂志》2006年第4期240-241,243,共3页Journal of Practical Diagnosis and Therapy

基　　金：湖南省教育厅基金资助项目(编号:02C409)

摘　　要：目的:探讨IL-18、IL-4和INF-γ在哮喘发病中的作用及其相互关系。方法:采用双抗体夹心EL ISA法检测36例哮喘患儿和24例性别、年龄相当的健康对照者血清IL-18、IL-4和INF-γ的含量。结果:与对照组相比,哮喘急性期患儿血清中IL-18和INF-γ的含量明显增高[IL-18:(210.32±81.12)vs(132.56±49.42)ng/L,P<0.01;INF-γ:(63.23±26.68)vs(46.96±18.52)ng/L,P<0.05],缓解期IL-18和INF-γ的含量降低;IL-4的含量降低[(208.28±90.56)vs(235.48±82.59)ng/L],但差异无统计学意义(P>0.05)。结论:哮喘患儿血清IL-18表达增高,增高的IL-18在调节T h细胞活性中起重要作用,参与了哮喘的病理过程。Objective To explore the role and potential relationship of IL-18, IL-4 and INF-γ and asthma pathogenesis. Methods The serum levels of IL-18, IL-4 and INF-γ were detected with ELISA assay in 36 asthmatic patients and 24 sex- and age-matched health control subjects. Results The levels of IL-18 and INF-γ in the patients with acute asthma were significantly higher compared to healthy control subjects EIL-18： （210.32±81.12） versus （132.56±49.42） ng/L,P〈 0. 01） INF-γ. （63.23 ± 26.68） vs （46.96±18. 52）ng/L,P 〈0.05]. The elevated IL-18 and INF-γlevels in acute asthma decreased on remission. Asthmatic patients showed lower plasma IL-4 levels than normal controls [（208. 28± 90. 56） versus （235. 48±82. 59） ng/L], but the differences were not statistically significant （P〉0.05）. Conclusion The IL-18 is high in patients and the elevated IL-18 level suggests the fact that IL-18 plays an important role in regulating the cells activity and is involved in asthma pathogenesis.

关 键 词：哮喘 白细胞介素18 白细胞介素4 Γ-干扰素 儿童 

分 类 号：R725.6[医药卫生—儿科]