阻塞性睡眠呼吸暂停低通气综合征93例临床分析  

Clinical analysis of 93 patients with obstructive sleep apnea hypopnea syndrome

作　　者：叶民[1] 徐晓梅[1] 谢于鹏[1] 陈少贤[1] 

机构地区：[1]温州医学院附属第一医院呼吸内科,浙江温州325000

出　　处：《中国实用内科杂志》2006年第4期510-512,共3页Chinese Journal of Practical Internal Medicine

摘　　要：目的 通过检测阻塞性睡眠呼吸暂停低通气综合征（OSAHS）患者血清血管内皮生长因子（VEGF）质量浓度，探讨其与肺动脉高压的关系。方法选择2003—02—2004—09温州医学院附属第一医院收治的93例因打鼾就诊的患者，对18例单纯鼾症、39例轻中度厦36例重度OSAHS患者于多导睡眠图（PSG）检测后次日晨7：00测定其血清VEGF质量浓度，井予超声心动图检测了其中3l例OSAHS患者肺动脉压力。结果 PSG检测结果显示与单纯鼾症组比，OSAHS组存在夜间低氧；且重度组比轻中度OSAHS组夜间低氧更严重（均有统计学意义）、与单纯鼾症组比较，VEGF质量浓度在重度OSAHS组中明显升高（P〈0，05），并分别与衡量病情及夜间低氧情况指标呈正相关，与夜间最低经皮血氧饱和度（SpO2）呈负相关。结论中重度OSAHS患者存在夜间低氧饱和度．同时有VEGF增高。Objective To investigate the serum levels of vascular endothelial growth factor （VEGF） in patients with obstructive sleep apnea hypopnea syndrome （OSAHS）, and make a primary relative study on the relationship between VEGF and pH. Methods Thirty-nine patients with mild to moderate OSAHS, 36 patients with severe OSAHS and 18 healthy snorers who had been admitted to the First Hospital Affiliated to Wenzhou Medical College from Feb. 2003 to Sep. 2004 were enrolled in this study. The serum levels of VEGF were detected in all patients at 7 ： 00 AM the next clay ＇after the detection of polysomnography （PSG） . Additionally 31 patients with OSAHS were detected by doppler echoeardiography to get the values of pulmonary artery, pression. Results There was nocturnal hypoxia in patients with OSAHS compared with healthy snorers, and the degree of nocturnal hypoxia was depended with the grade of OSAHS （ both achieved statistical difference） by the detection of PSG. The levels of VEGF was significantly higher in patients with severe OSAHS than in healthy snorers （P 〈 0. 05 ） . VEGF were positively related to apnea-hypopnea index （AHI）, the disturbance index of hypoxemia, the percentage of the period with nocturnal SpO2 less than 90% in total sleep time and the longest duration of hypoxemia, and VEGF were negatively related to nadir of SpO： （ r = 0. 233, r = 0. 222, r = 0. 237, r = 0. 240, r = - 0. 240, P 〈 0. 05 ） . Among 31 patients with OSA HS, two patients had pulmonary hyertension （6. 5 % in total） . The sen, m levels of VEGF was not related to pulmonary artery pression （r = -0. 082, P =0. 730）. Conclusion The serum levels of VEGF is significantly higher and there is nocturnal hypoxia in patients with moderate and severe OSAHS.

关 键 词：睡眠呼吸暂停综合征 血管内皮生长因子 肺动脉高压 血清 

分 类 号：R563[医药卫生—呼吸系统]