活络健骨胶囊镇痛试验的药效学研究  

Pharmacodynamic Studies of Huoluojiangu Capsule on Analgesic Experiments

作　　者：周家茂[1] 严奉祥[2] 全建设[1] 周继[1] 陈雄新[1] 李葵香[1] 余平[1] 殷世柱[1] 聂兰秀[1] 陈羿汐[1] 谢蓝[1] 

机构地区：[1]湖南环境生物学院医学部,湖南衡阳421001 [2]南华大学药物药理研究所,湖南衡阳421001

出　　处：《中国中医药信息杂志》2006年第4期25-27,共3页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：湖南省教育厅资助课题(05D031);湖南省教育厅重点资助课题(03A040);湖南省卫生厅资助项目(204062);教育部重点基金资助项目(204095)

摘　　要：目的观察活络健骨胶囊的实验镇痛效应。方法分别采用扭体、电刺激及热板法三种镇痛试验。每种实验又将60只小鼠随机分成6组并给予不同药物灌胃:A组(空白对照),生理盐水0.25mL/10g;B组(阳性对照),双氯芬酸3.5mg/kg;C组(阳性对照),哌替啶15mg/kg;D、E、F组分别为试药低、中、高剂量活络健骨胶囊(剂量分别为14、21、28g/kg)。然后在预处理后的不同时间分别观察药物对化学、电极热板刺激痛反应的影响。结果活络健骨胶囊低、中、高剂量组均能抑制化学刺激鼠扭体反应,与空白组比较,低剂量组显效(P<0.01);中、高剂量组作用更强(P<0.001)。对于电刺激鼠嘶叫反应,与空白组比较,低剂量组有效(P<0.05);中、高剂量组显效(P<0.01)。亦能明显延长小鼠对热板刺激引起痛反应的时间,各试药组与空白对照组比较(P<0.05);活络健骨胶囊与B、C组之间在30、60、120min镇痛作用基本相同(P>0.05),但在180min时阳性对照药不及活络健骨胶囊的效应(P<0.05)。结论活络健骨胶囊具有良好镇痛作用,其作用比哌替啶(小鼠灌胃)慢而持久,其镇痛强度大于双氯芬酸。Objective To observe effect of Huoluojiangu capsule （HJC） on analgesic experiments. Methods The 3 kinds of analgesic experiments of whirling body, electric irritation and hot board were respectively adopted in mice. 60 mice were randomly divided into 6 groups in every analgesic experiment： A group（blank control）, normal saline 0.25 mL/10 g. B group （positive control）, diclofenac sodium 3.5 mg/kg; C group （positive control）, pethidine 15 mg/kg, D,E and F group were respectively as low,mid and high dose of HJC groups （HJC 14, 21, 28 g/kg）. Afterward, effects of HJC on ache induced by chemistry, electricity and heat were respectively observed at different time after pretreatments.Results Low, mid and high dose of HJC groups can all inhibit reaction of whirling body by chemical irritation. Compared with blank control group, low dose of group had evidently effect, P〈0.01. Mid and high dose of HJC groups had stronger effect （P〈0.001）. As for braying reaction by electric irritation, low dose of group was effective （P〈0.05）, and mid and high dose of HJC groups had evidently effect （P〈0.01）, compared with blank control group. Every group of HJC can also markedly prolong period of pain reaction by hot board compared with blank control group, P〈0.05. Analgesic effect of HJC was not different from positive groups （B and C group） at 30, 60 and 120 rain （P〉0.05）, but it had stronger analgesic effect than positive groups （B and C groups） at 180 min, P〈0.05. Conclusion HJC possesses better analgesic effect, its action was slower and longer than pethidine （pouring stomach） and its potency was larger than diclofenac sodium.

关 键 词：活络健骨胶囊:镇痛试验 药效学 

分 类 号：R285.5[医药卫生—中药学]