SARS患者痰液嗜麦芽窄食单胞菌的动态监测与意义  

Dynamic monitoring of sputum Stenotrophomonas maltophilia in patients with severe acute respiratory syndrome

作　　者：朱明利[1] 娄国强[1] 朱秀亚[1] 章松平[1] 刘寿荣[1] 卢德荣[1] 

机构地区：[1]杭州市第六人民医院浙江中医学院附属第六医院杭州市传染病医院,浙江杭州310014

出　　处：《中国微生态学杂志》2006年第2期104-106,共3页Chinese Journal of Microecology

摘　　要：目的探讨嗜麦芽窄食单胞菌的动态检测对严重急性呼吸综合征(SARS)的临床意义。方法仪器和手工法动态监测3例重症和1例轻症患者痰液中嗜麦芽窄食单胞菌的定量变化和耐药性,同时观察K-B法药敏试验中L型的诱导情况及变异趋势。结果3例重症SARS患者共42次痰液和1次胸腔引流液培养中,35份分离出来嗜麦芽窄食单胞菌L型,形态以长丝体为主。结论动态监测重症SARS患者痰液中嗜麦芽窄食单胞菌有重要意义,多种抗生素可诱导其发生L型变异,应随时注意其变异趋势。Objective To explore the clinical significance of dynamic observation of S. maltophilia in,patients with SARS. Methods S. maltophilia in sputum from 3 cases of critical and 1 of mild type patient with SAILS was examined continuously. L variation in antimicrobial susceptibility test performed by Kirby-Bauer method was also observed. Results 35 strains of S. maltophilia were isolated from 42 samples of sputum and one of hydrothorax,they were resistant to most antibiotics. Semi-fixed quantity of sputum correlated with the state of illness, and polymorphic S. maltophilia L-forms i.e. filamentous were found in bactefiostatic zone in K-B method. Conclusions Dynamic observation of S. maltophilia drug-resistance in patients with critical SARS was valuable, and it must pay attention that S. maltophilia may be induced to L-forms by many antibiotics.

关 键 词：严重急性呼吸综合症 嗜麦芽窄食单胞菌 耐药性 细菌L型 

分 类 号：R563.8[医药卫生—呼吸系统]