单纯性肥胖儿童血脂类、内皮素、糖耐量变化的意义  

Significance of Changes of Blood Lipids,Endothelin and Carbohydrate Tolerance in Simple Obesity Children

作　　者：黄丽君[1] 冯国富[2] 陈正跃[1] 

机构地区：[1]新乡医学院病理生理学教研室 [2]新乡市第一人民医院儿科,河南新乡453000

出　　处：《实用儿科临床杂志》2006年第7期404-405,共2页Journal of Applied Clinical Pediatrics

摘　　要：目的研究不同程度单纯性肥胖儿童血总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白(LDL)、内皮素(ET)及糖耐量变化。方法选择单纯性肥胖儿童436例,其中轻度单纯肥胖242例、中度单纯肥胖138例、重度单纯肥胖56例。对照组儿童80例。检测各组儿童血TC、TG、LDL、ET、糖耐量。结果单纯肥胖患儿血TC、TG、LDL、ET明显高于对照组,各项之间均有显著性差异,且增高程度与体质量呈正相关;重度单纯肥胖患儿中4例糖耐量异常,对照组无异常。结论单纯性肥胖儿童血脂类和ET表达水平均有增高,个别重度肥胖患儿有糖耐量下降情况,应对单纯性肥胖儿童进行早期干预。Objective To investigate the changes of blood lipid, endothelin（ET）and carbohydrate tolerance in simple obesity children. Methods Serum total cholesterol（TC）, triglyeride（TG）, low density lipoprotein（LDL）, endothelin（ET） and oral glucose tolerance test （OGTT） of 436 cases（ light obesity group 242, moderate obesity group 138, heavy obesity group 56） were detected respectively. Re- sults The levels of TC,TG,LDL,ET and OGTT in 3 simple obesity groups were all higher than those in control group obviously and there were significant differences. The significant positive correlation between the obesity children serum lipids,ET and obese degrees were observed. Four insulin resistant children were found in heavy obesity group and none in other groups. Conclusions The levels of serum lipids and ET increases in obesity children and the OGTT decreases in some heavy obesity children. For preventing the obesity related health problems, the simple obesity children should be paid more attention to earlier.

关 键 词：肥胖症 血脂 内皮素 糖耐量 儿童 

分 类 号：R723.14[医药卫生—儿科]