慢性结节状胃炎与幽门螺杆菌的关系  

Relationship between Chronic Nodular Gastritis and Helicobacter Pylori Infection in Children

作　　者：胡志红[1] 苗芸[1] 肖咏梅[1] 沈鸣[1] 

机构地区：[1]上海交通大学医学院附属儿童医院消化科,上海200040

出　　处：《实用儿科临床杂志》2006年第7期412-413,共2页Journal of Applied Clinical Pediatrics

摘　　要：目的观察儿童慢性结节状胃炎幽门螺杆菌(Hp)感染状况及病理组织学改变。方法对经胃镜检查有结节状改变的慢性胃炎患儿41例,男17例,女24例,进行快速尿素酶试验和病理组织学检查,并进行血清Hp抗体检测。所有患儿用奥美拉唑、阿莫西林、克拉霉素三联除菌治疗,3个月后行胃镜随访。结果结节状胃炎41例患儿中Hp感染39例,感染率95%;胃黏膜活检病理显示所有病例均有慢性炎性细胞浸润,且黏膜固有层内淋巴细胞增多,淋巴滤泡形成。所有患儿经成功除菌治疗3个月后36例胃镜随访胃窦部结节状隆起消失,病理证实淋巴滤泡消失,炎性细胞明显减少。结论儿童慢性结节状胃炎是一种特殊类型的胃炎,为儿童Hp感染后的典型表现,Hp根除治疗是儿童结节性胃炎有效的治疗方法。Objective To observe helicobacter pylori（Hp） infection chronic nodular gastritis and its histo-pathology change in children. Methods Forty-one chronic gastritis patients with nodularity discovered by gastroendoscopy had taken Hp infection examination and eradication of Hp. All patients were given a triple therapy consisted of omeperazole, amoxcillin and clarithromycin, and observed by gastroendoscopy after 3 months. Results Thirty-nine of 41 cases of the chronic nodular gastritis were confirmed Hp infection. The infection percentage was 9596. Pathologic examine of gastric mucosa biopsy displayed all 41 cases of chronic inflammation cell presenting,along with lymphoid cells increasing in mucous membrane, and lymphoid follicles formation. After 3 months of successful Hp eradication, 36 of 41 patients following up by gastroacopy indicated disappearance of gastric nodule. The pathologic examine confirmed the lymph follicles vanished, and the inflammation cell obviously reduced. Conclusions The child chronic nodular gastritis is a special type of gastritis, a typical manifestation after Hp infection. Eradication of Hp is a valid treatment for chronic nodular gastritis in children.

关 键 词：胃炎 慢性 结节状改变 螺杆菌 幽门 根除治疗 

分 类 号：R725.7[医药卫生—儿科]