类风湿关节炎发病过程中的血管新生调节因子  

Regulative factors of angiogenesis in the episode of rheumatoid arthritis

作　　者：林莉[1] 王彤[2] 王杰[2] 

机构地区：[1]沈阳医学院附属卫生学校,辽宁省沈阳市110034 [2]沈阳医学院生化及分子生物学教研室,辽宁省沈阳市110034

出　　处：《中国临床康复》2006年第16期124-126,共3页Chinese Journal of Clinical Rehabilitation

摘　　要：目的:分析比较各种血管新生调节因子在类风湿关节炎发病过程中的作用途径,为类风湿关节炎靶向治疗提供理论依据。资料来源:应用计算机检索Medline1985-01/2005-05有关血管新生和类风湿关节炎发病机制方面的文献,检索词为“Rheumatoid,Osteoarthritis,Vascularendothelialgrowthfactor,Vasculargrowthmediatedfactor”,并限定文章语言种类为英文。资料选择:对资料进行初审,选取有关血管新生和类风湿关节炎发病机制方面的文献,筛除非随机对照实验、重复实验和综述,对剩余的文献开始查找全文。资料提炼:共收集了123篇有关血管新生和类风湿关节炎发病机制方面的文献,10篇符合纳入标准,排除113篇。对10篇文献中提及的血管内皮细胞生长因子、成纤维细胞生长因子、转化生长因子β、整联蛋白αvβ3、肿瘤坏死因子α、血小板源性内皮细胞生长因子、血小板源性生长因子、肝细胞生长因子及白细胞介素8等血管新生抑制和促进因子在类风湿关节炎血管新生中的作用及其途径进行综合分析。资料综合:将所选资料按照以下顺序归纳总结:①类风湿关节炎的组织学改变。②类风湿关节炎与血管新生的关系。③血管新生抑制和促进因子在类风湿关节炎发病中的作用途径。结论:类风湿关节炎的病程发展与局部血管新生有密切关系,多种因子参与并调控了这一过程。血管内皮细胞生长因子、成纤维细胞生长因子、整联蛋白αvβ3、血小板源性内皮细胞生长因子、血小板源性生长因子、肝细胞生长因子及白细胞介素8均被证明可促进血管新生,而转化生长因子β、肿瘤坏死因子α的作用是双重的。另外,血管新生抑制因子也参与调节血管新生。因此,上述因子在类风湿关节炎的发生与发展中起重要作用。OBJECTIVE： To analyze effective way of various vascular regulative factors in the episode of rheumatoid arthritis （RA） and provide theoretical basis for RA targeting therapy. DATA SOURCES： The relevant articles on vascular renascence and episode of RA published between January 1985 and May 2005 were searched in Medline database with the key words of ＂Rheumatoid, Osteoarthritis＇, Vascular endothelial growth factor, Vascular growth mediated factor＂ in English. STUDY SELECTION： The articles about the same content as above were selected by primary trial. The studies on vascular renascence and episode of RA were selected. Those non-randomized controlled trial, repetitive trial and reviews were screened out. The full-texts were retrieved in leftover literatures. DATA EXTRACTION： Totally 123 articles about the vascular renascence and episode of RA were collected. Ten papers were accorded with the inclusive criteria and 113 articles were excluded. In the 10 articles, vascular endothelial growth factor （VEGF） fibroblast growth factors （FGFs）, transforming growth factor-β （TGF-β）, integrin （α,β3）, tumor necrosis factor-α （TNF-α）, platelet derived-endothelial cell growth factor （PD-ECGF）, platelet derived growth factor （PDGF）, hepatocyte growth factor （HGF）, Interleukin-8 （IL-8） etc. were mentioned, and their functions and mechanisms of angiogenesis activator and inhibitor in RA occurrence were reviewed. DATA SYNTHESIS： The selected data were summarized in the following order： ①Histological change in RA. ②The relationship between RA and angiogenesis. ③The functions and mechanisms of angiogenesis activator and inhibitor in RA occurrence. CONCLUSION： Local angiogenesis correlates closely with RA progress. Many kinds of factors involve in this process. It has been testified that VEGF, FGFs, Integrinα,β3, PD-ECGF, PDGF, HGF, IL-8 promote angiogenesis, while TGF-β,TNF-α have dual function. Besides, angiogenesis inhibitor also regulates angiogen

关 键 词：关节炎 类风湿 滑膜 新生血管化 病理性 内皮生长因子 

分 类 号：R593.22[医药卫生—内科学]