中西药治疗退变颈椎间盘的实验研究  

Experimental study on the degenerated cervical intervertebral discs with Chinese and western medicine

作　　者：赵晓勇[1] 王海涛[1] 刘福成[1] 苏江宁[1] 孙喜龙[1] 刘越[1] 陈涛平[1] 

机构地区：[1]河北省人民医院,石家庄050051

出　　处：《中国中医骨伤科杂志》2006年第2期1-4,共4页Chinese Journal of Traditional Medical Traumatology & Orthopedics

基　　金：河北省科学技术研究与发展计划项目;编号:03276196D-50

摘　　要：目的:了解家兔退变颈椎间盘内细胞因子、蛋白多糖及血清超氧化歧化酶(SOD)的变化情况,观察中西药联合应用对其含量的影响。方法:通过切除家兔颈背部浅层、全层肌肉,造成颈动力失衡,诱导颈椎间盘退变,建立颈椎退变模型,给予中西药治疗一个月,测定退变颈椎间盘中细胞因子、蛋白多糖及血清SOD含量变化。结果:模型组与正常对照组相比较,颈椎间盘中IL-1β、TNFα含量均明显升高,蛋白多糖、血清SOD明显降低,中西药治疗IL-1β、TNFα含量明显降低、蛋白多糖、血清SOD明显升高,血清中SOD含量与椎间盘蛋白多糖含量呈正相关。结论:抗骨增生胶囊与葡立胶囊联合应用对退变颈椎间盘多种细胞因子和炎症介质有明显的抑制作用,可明显恢复颈椎间盘蛋白多糖含量、血清SOD活力,抑制退变过程,修复退变椎间盘。Objective：To comprehend the effect on the changes of the contents of cytokine,proteoglycan and SOD in rabbits＇degenerated cervical intervertebral discsMethods：By removing superficial and whole layer muscles, the model of degenerated cervical intervertebral discs in rabbits were created and applied to examine the contents of cytokine,proteoglycan and SOD under the therapy of Chinese andwestern medicine for a month. Results：Compared with control group of rabbits, the contents of IL-1β,TNFα increased significantly while the contents of proteoglycan and SOD significantly decreased in rabbits＇model group. But after the treatment of Chinese and western medicine, the contents of IL- 1β,TNFα decreased while the contents of proteoglycan and SOD increased greatly and there is a positive correlation between SOD in blood serum and proteoglycan in cervical inervertebral discs. Conclusions： Anti-hyperosteogeny capsule in combination with glucosemine hydrochloride capsule can inhibit inflammatory reaction, relieve cytokine products and enhance the contents of proteoglycan and SOD vitality.

关 键 词：椎间盘退变 细胞因子 蛋白多糖 SOD 抗骨增生胶囊 葡立胶囊 实验研究 

分 类 号：R681.5[医药卫生—骨科学] R473.5[医药卫生—外科学]