服用莫达非尼对48h睡眠剥夺条件下模拟飞行操作能力的影响  

Effects of Modafinil on Simulated Flight Performance during 48 h Sleep Deprivation.

作　　者：詹皓[1] 景百胜[1] 李砚锋[1] 郭华[1] 李彤[1] 韦四煌[1] 唐桂香[1] 

机构地区：[1]空军航空医学研究所,北京100036

出　　处：《航天医学与医学工程》2006年第2期102-105,共4页Space Medicine & Medical Engineering

基　　金：空军后勤科研计划项目(KH0108011)

摘　　要：目的观察48h睡眠剥夺（sleep deprivation，SD）条件下正常人服用莫达非尼改善模拟器飞行操作能力的效果。方法以6名健康男性青年志愿者为对象，在间隔2周的两次48hSD（从第1天8：00至第3天8：00）实验中交叉服用莫达非尼和安慰剂（于实验第2天0：00、16：00和第3天0：00服用，每次200mg），于第1天21：00及每次服药后1h、3h、5h、7h进行J7-E模拟器飞行操作测试。结果安慰剂组的模拟器飞行成绩随SD时间延长逐渐下降，在第3天1：00—7：00的飞行成绩明显降低：操作错误随着SD延长而增加，在第3天1：00—7：00的出错次数增多，并且左上转弯和着陆阶段的操纵错误较多。与安慰剂组相比，莫达非尼组的飞行成绩在第3次服药后明显提高。莫达非尼组48h SD总的操作错误数较安慰剂组降低了19％，第3天1：00—7：00的错误数较安慰剂组降低了40％。结论服用莫达非尼明显改善48hSD条件下的模拟飞行操作能力，在SD复合生物节律的影响时药效更明显。Objective To investigate the effects of modafinil, a new wake-promoting agent, on simulated flight performance during 48 h sleep deprivation（SD）. Method Six male healthy young volunteers were exposed to two periods of 48 h continuous wakefulness during the crossover experiment. In one period, three 200 mg doses of modafinil were given and in the other, separated by two weeks, matching placebos were administered. The SD time started from 8：00 of the first day to 8：00 of the third day. Drug was given at 0.00,16：00 of the second day and 0.00 of the third day. Flight performance in JT-E flight simulator was tested at 21：00 of the first day and 1 ,3,5,7 h after each drug administration. Result The scores of simulated flight performance in the placebo group decreased with time during SD and became significant at 1 ：00 - 7：00 of the third day. Numbers of errors increased with time during SD, especially in the left ascending turn stage and the descending ＆ landing stages. Compared with the placebo, flight performance was significantly increased after the third administration of modafinil. Numbers of errors during 48 h SD and at 1 ：00 - 7：00 of the third day in modafinil group was 19% and 40% lower than those in placebo group respectively. Conclusion Simulated flight performance during 48 h SD is significantly improved after repeated administration of modafinil, especially when the impacts of SD and the circadian trough are combined.

关 键 词：睡眠剥夺 中枢神经系统药物 促醒剂 莫达非尼 飞行模拟 工作能力 飞行模拟器 

分 类 号：R859[医药卫生—航空、航天与航海医学]