川芎嗪与ACEI联用对伴轻度高血压2型糖尿病患者尿α_1-MG、β_2-MG的影响  

Effect of Ligustrazine and low dosage ACEI on the output of α_1-Microglobulin and β_2-Microglobulin in urine of typeII diabetes millitus with non-hypertension or hypertension

作　　者：张昌玉[1] 孙志桂[1] 田玉峰[1] 

机构地区：[1]日照市人民医院,山东日照276826

出　　处：《泰山医学院学报》2005年第4期319-322,共4页Journal of Taishan Medical College

摘　　要：目的探讨川芎嗪并用ACEI对伴轻度高血压2型糖尿病患者尿α1-微球蛋白(α1-MG)、β2-微球蛋白(β2-MG)的影响。方法45例2型DM患者均伴轻度高血压,随机平均分成两组,治疗组(23例)服ACEI-苯那普利并用川芎嗪注射液,对照组(22例)服ACEI-苯那普利;分别与服药前及后2周、4周、8周用放射免疫法(RIA)测定患者尿α1-MG、β2-MG及尿白蛋白(Alb)。比较两组服药前后血压的变化。结果川芎嗪并用ACEI对伴轻度高血压2型糖尿病患者尿α1-MG、β2-MG排泄量的降低作用较单用ACEI类药的降低作用更明显(P<0.01),且对α1-MG的降低作用更显著(P<0.01)。其降低α1-MG、β2-MG及AER的作用与其降低血压的作用无明显相关关系(P>0.05)。结论ACEI类药非常适用于T2DM患者,尤其是α1-MG、β2-MG升高者,不论其血压正常或轻度升高。但合用川芎嗪其疗效更佳。这对阻止DN的发生及发展有着非常重要的临床意义。Objective： To study the effect of ligustrazine and low dosage angiotensin converting enzyme inhibitor （ACEI） -benazepril on α1-microglobulln（ α1 -MG） andβ2-microglobulin（ β2 -MG）out of urine of type 2 diabetes mil litus（ T2DM） with non- hypertension or hypertension. Methods： Forty-five cases with T2 DM associated with non - hypertension or hypertension were randomly divided into 2 groups. 23 cases were in the treatment group and recevied ligustrazine and ACEI - benazepril. 22 cases of only ACEI were in the control group. The treatment and control groups included 16 cases of high blood pressure, and the relationship of the variation of the blood pressure between the control and treatment groups were compared before and after the adminitration. Theα1 - MG - MG and α1buminuria（Alb） were measured by the method of ratioimtnuncoasay （RIA） before and after the administration for 2 weeks, 4 weeks and 8 weeks . Results： The ligustrazie and ACEI- benazepril reduced α1 - MG and β2 - MG significantly （ P 〈 0.01） in T2DM with non - hypertension or hypertension, but the α1-MG reduced more significantly （ P 〈 0.01 ） compared with the β2- MG. The reduction of α1 - MG and β2 - MG was not significantly related （ P 〉 0.05） with the decrease of blood pressure. Coclusion： The ligustrazine and low dosage benazepril are fit for the treatment of the T2DM patients with the higherα1 - MG, either with hypertension or non hypertension, and has effect on the prevention of the development of DN.

关 键 词：川芎嗪 血管紧张素转换酶抑制剂 2型糖尿病 高血压 尿微球蛋白 

分 类 号：R587.1[医药卫生—内分泌]