特戊酸氯甲酯合成新工艺的研究  

A novel synthesis of chloromethyl pivalate

作　　者：王玉民[1] 曹晓群[1] 朱焰[1] 张昌军[1] 庞现红[1] 

机构地区：[1]泰山医学院化学化工学院,山东泰安271000

出　　处：《泰山医学院学报》2005年第4期346-347,共2页Journal of Taishan Medical College

摘　　要：目的探讨合成特戊酸氯甲酯的简便工艺方法。方法以己内酰胺作催化剂,特戊酸和氯化亚砜室温反应得到特戊酰氯,不经分离,补加适量氯化亚砜后直接与氯化锌和多聚甲醛室温反应合成特戊酸氯甲酯。结果特戊酸氯甲酯总收率94.2%,产品结构经IR,1H NMR确认。结论该法一步完成,条件温和,操作简单,值得进一步进行工业化开发。Objective： To study the simple synthetic methods of chloromethyl pivalate. Methods： Pivaloyl chloride was prepared by the reaction of pivalic acid with thionyl chloride in the presence of ε-Caprolactam in a chlorinated hydrocarbon medium （methylene chloride） at 20 ℃-35 ℃ with paraformaldehyde in the presence of Zinc chloride and thionyi chloride in methylene chloride at 20 ℃ -35 ℃. Results： The yield of chloromethyl pivalate was 94.2%. Its structure was confirmed by IR and 1H NMR. Conclusion： The one-step method is simple and valuable for further development in industry.

关 键 词：特戊酸 酯化 特戊酸氯 甲酯 

分 类 号：TQ225.24[化学工程—有机化工]