5-氨基-4-氧代戊酸盐酸盐的制备  

Synthesis of 5-Amino-4-oxopentanoic Acid Hydrochloride

作　　者：李丽[1] 谭丹[1] 林原斌[1] 

机构地区：[1]湘潭大学化学学院

出　　处：《中国医药工业杂志》2006年第4期223-224,共2页Chinese Journal of Pharmaceuticals

基　　金：湖南省教育厅资助项目(03C461)

摘　　要：乙酰丙酸经酯化、溴化得到5-溴或3-溴-4-氧代戊酸甲酯混合物,无需分离,直接与邻苯二甲酰亚胺钾在DMF中反应得N-[(2-氧代-4-甲氧羰基)丁基]邻苯二甲酰亚胺,最后经稀盐酸酸解得到5-氨基-4-氧代戊酸盐酸盐,总收率接近 44％。5-Amino-4-oxopentanoic acid hydrochloride was synthesized from levulinic acid by esterification and bromination to give methyl 5- or 3-bromolevulinates, which was subjected to reaction with potassium phthalimide without separation in presence of DMF followed by acidolysis with an overall yield of 44%.

关 键 词：5-氮基-4-氧代戊酸 中间体 制备 

分 类 号：O625.636[理学—有机化学]