奥司他韦治疗流感疑似病例疗效观察  

The curative effect of oseltamivir on borderline case of influenza

作　　者：王孙尧[1] 颜伟朝[1] 陈明明[2] 

机构地区：[1]浙江省杭州市红十字会医院,浙江杭州310003 [2]浙江省立同德医院,浙江杭州310012

出　　处：《儿科药学杂志》2006年第2期24-26,共3页Journal of Pediatric Pharmacy

摘　　要：目的:探讨奥司他韦治疗流感疑似病例的疗效。方法:60例流感疑似病例随机分为2组,治疗组30例口服奥司他韦2mg/(kg.次),2次/d,对照组30例静脉滴注利巴韦林10mg/(kg.d),疗程均为5d。结果:总有效率治疗组86.7%,对照组40.0%,两组比较差异有统计学意义(P<0.01);平均退热时间治疗组(1.5±1.01)d,对照组(2.77±1.14)d,两组比较差异有统计学意义(P<0.01)。结论:奥司他韦治疗流感疑似病例疗效显著,在流感流行季节,根据流行病学史和临床表现基本上可以作出流感早期诊断。Objective： To investigate curative effect of oseltamivir on borderline ease of influenza. Methods： 60 patients were divided into 2 groups randomly. Treatment group of 30 eases were given oseltanaivir 2 mg/kg, twice daily by mouth; control group of 30 eases were given ribavirin 10 mg/（kg.d） by vein. Results： Total effective rate of the treatment group was 86.7%, and the rate of control group was 40.0%. The total effective rate of treatment group was higher than that of control group （P 〈 0.01 ）. The average time needed to reduce fever for the treatment group was （1.5 ± 1.01） days, and that for the control group was （2.77 ± 1.14） days and the time needed to reduce fever of treatment group was shorter than that of control group （P 〈 0.01 ）. Conclusions： Oseltamivir can effeetively treat the borderline ease of influenza during the period when influenza is prevailing and an early diagnosis of influenza can be made according to the epidemiology and clinical situation.

关 键 词：流行性感冒 奥司他韦 利巴韦林 

分 类 号：R978.7[医药卫生—药品] R725.6[医药卫生—药学]