冠心病患者血清转化生长因子β_1检测的临床意义  

Clinical Significance of Serum Transforming Growth Factor-β_1 Measurement in Patients with Coronary Heart Disease

作　　者：杨春凯[1] 兰玉怀[1] 杨善军[2] 

机构地区：[1]黑龙江省医院心内科,黑龙江哈尔滨150036 [2]黑龙江中医药大学附属第二医院,黑龙江哈尔滨150040

出　　处：《中国初级卫生保健》2006年第4期88-90,共3页Chinese Primary Health Care

摘　　要：目的通过分析冠心病患者血清转化因子β1(TGF-β1)与冠状动脉病变程度及冠心病患者心功能的关系,以探讨冠心病患者血清TGF-β1水平变化的临床意义。方法挑选研究对象66例,分为:冠心病组(CHD)和冠状动脉正常组,前者又分为急性心肌梗死组(AMI组)和心绞痛组(AP组),并以冠状动脉正常组为对照组(Control组)。所有对象均填写调查表,择日行冠状动脉造影术,术前采股动脉血,采用ABC双抗体夹心ELISA法检测血清TGF-β1浓度,入院2周内完成超声心动检查,所有资料用SPSS11.1处理。结果AMI组和AP组血清TGF-β1水平均显著低于对照组(P<0.01),而AMI组和AP组间差异未见统计学意义;直线分析显示对冠心病发病有影响者为冠心病家族史和TGF-β1,对急性心肌梗死发病有影响者为TGF-β1。结论急性心肌梗死患者和心绞痛患者TGF-β1血清水平明显减低。TGF-β1可能对冠心病及急性心肌梗死的发病有影响。OBJECTIVE We designed the present study to investigate the clinical significance of the alterations of the circulating levels of transforming growth factor-β1 （TGF-β1） in patients with coronary heart disease （CHD）, METHODS The study group comprised 60 patients with coronary heart disease （CHD） and 28 control subjects. The CHD patients were subdivided into 2 groups： with acute myocardial infarction （AMI） and angina pectoris （AP） , Patients undergone semi quantitative coronary angiography, and all patients undergone echocardiography, Serum TGF-β1 was detected using ELISA method in all subjects. RESULTS Serum TGF-β1 level significantly reduced in 60 patients with CHD compared with the controls （P〈0,01） . Patients with AMI showed a lower serum level of TGF- β1 than patients with AP. CONCLUSION The findings suggested that serum levels of TGF-β1 reduced in patients with CHD, especially in patients with AMI, TGF-β1 showed some extent protective effect to coronary artery,

关 键 词：转化生长因子Β1 冠心病 急性心肌梗死 

分 类 号：R541.4[医药卫生—心血管疾病]