豚鼠体癣模型表皮郎格罕细胞的动态观察  

Observations of Epidermal Langerhans Cells in Dermatophyte Infection Model in Guinea Pigs.

作　　者：王忠永[1] 谭升顺[1] 吴绍熙[1] 郭宁如[1] 

机构地区：[1]山东省滨州医学院附院皮肤科,西安医科大学第二附属医院皮肤科,中国医学科学院皮肤病研究所

出　　处：《中国皮肤性病学杂志》1996年第1期9-10,共2页The Chinese Journal of Dermatovenereology

摘　　要：应用ＡＴＰａｓｅ组化法对豚鼠实验性皮肤真菌病进行皮损表皮ＬＣ的动态观察。结果发现，在感染非治疗侧，ＬＣ受损，其密度明显降低，与正常对照例及感染治疗侧比较差异均有显著性意义。说明皮肤真菌感染后可造成皮损表皮ＬＣ的减少，从而引起一系列免疫病理变化。The kinetic changes in morphology and cellular density of epidermal Langerhans cells(LC) in the guinea pigs infected with trichophyton mentagrophytes were observed by adenosine triphosphatase(ATPase),cytochemica staining technique after treated and non-treated by miconazole nitrate cream.The results showed that the number of LC of the infectednon-treated group was diminished significantly compared with normal controls in 14,21,28 days(P<0.001 ),and there was significant difference in the density of epidermal LC between treated group and nontreated group(P<0.001).It suggests the close correlation of LC with the immunopathologic changes in experimental dermatomycosis.

关 键 词：体癣 动物实验 豚鼠 郎格罕细胞 

分 类 号：R756.202[医药卫生—皮肤病学与性病学]