巨块型宫颈癌Ⅰ_(B2)～Ⅱ_B期68例术前全身新辅助化疗的近期疗效观察  

The therapeutic value of preoperative neoadjuvent chemotherapy in patients with stage ⅠB ～ⅡB bulky cervical cancer

作　　者：赵淑萍[1] 王泽华[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院妇产科,湖北武汉430022

出　　处：《中国实用妇科与产科杂志》2006年第4期271-273,共3页Chinese Journal of Practical Gynecology and Obstetrics

摘　　要：目的探讨术前新辅助化疗对巨块型宫颈癌的近期疗效。方法选择2001年12月至2004年12月华中科技大学同济医学院附属协和医院初治的经病理确诊的68例ⅠB2～ⅡB期巨块型宫颈癌,采用PVB方案化疗2个疗程后手术,观察近期的疗效。结果临床近期有效率达75%,手术切除率达100%。术前新辅助化疗可提高手术切除率和症状改善率,化疗后肿瘤直径较化疗前有不同程度的缩小,差异有显著意义(P<0.05)。所有手术患者均能顺利切除病灶并达到切缘距离病灶1cm以上。结论术前新辅助化疗可提高宫颈癌的近期疗效,成为治疗该病的一种新手段,具有重要的临床意义。Obiective To investigate the effect of preoperative neoadjuvant chemotherapy on ⅠB2～ⅡB bulky cervical cancer. Metheds Totally 68 eases of primary bulky cervical cancer in stage ⅠB2～ⅡB were diagnosed by pathology in Union Hospital ,Tongji Medical College between 2001 and 2004. They were managed by regimen of PVB chemotherapy for 2 cycles and followed by operation. Results The overall response rate was 75%. The rate of surgery after chemotherapy was 100%. Preoperative neoadjuvant chemotherapy could apparently increase the chance of operation and perfect the remission rate. The primary tumor sizes were significantly decreased after chemotherapy compared with that of before（ P 〈 0. 05 ）. All patients underwent radical hysterectomy easily and the edge of surgical specimens between local primary tumor reached more than lcm. Conclusion Neoadjuvant chemotherapy is a new and effective method for treatment of stage ⅠB2～ⅡB bulky cervical cancer. It shows promising prospect in clinical application.

关 键 词：新辅助化疗 宫颈肿瘤 手术治疗 

分 类 号：R71[医药卫生—妇产科学]