活血化瘀中药对清解通下中药增效作用的实验研究I——治疗急性细菌性腹膜炎的实验观察  

Experimental Study on Synergistic Action of Huoxue Huayu(活血化瘀) Herbs on Qingjie Tongxia(清解通下) Herbs I—Effects on Acute Bacterial Peritonitis in Rats

作　　者：尚晓滨[1] 吴咸中[2] 李东华[2] 郭世铎[2] 

机构地区：[1]天津医科大学,博士研究生天津300070 [2]天津市中西医结合急腹症研究所

出　　处：《中国中西医结合外科杂志》2006年第2期91-94,共4页Chinese Journal of Surgery of Integrated Traditional and Western Medicine

基　　金：天津市科委重点支持课题(023111511)

摘　　要：目的:通过大鼠急性细菌性腹膜炎动物模型,观察联合应用活血化瘀和清解通下中药对急性腹膜炎的治疗效果。方法:采用盲肠结扎加穿孔法(CLP)制作急性细菌性腹膜炎动物模型,分别经口投予复方丹参方、加味小承气汤以及二者合用(活血清下汤),观察腹腔脏器的病理损害,以及腹膜的渗出与吸收功能。结果:活血清下汤组病理损害最轻,腹膜的渗出受到抑制,对蛋白的吸收功能增强。结论:二方合用优于单方,表明活血化瘀中药对清解通下中药存在增效或协同作用。Objective To observe multi-effects of Huoxue Qingxia decoction on acute bacterial peritonitis in order to verify that Huoxue Huayu herbs can enhance the effects of Qingjie Tongxia herbs Methods Animal model of acute bacterial peritonitis were established with cecal ligation plus puncture （CLP）, and was observed the histomorphologic change of organs treated by Huoxue Qingxia decoction. Moreover the influence of Huoxue Qingxia decoction on the ability of peritoneal exudation and absorption was investigated. Results Treated with Huoxue Qingxia decoction, the histomor phologic changes of organs were reduced with increased absorption of albumin and decrease peritoneal exudation to the abdominal cavity. Conclusion Acute bacterial peritonitis can be satisfactorily treated with Huoxue Huayu herbs and Qingjie Tongxia herbs, preferable to either one.

关 键 词：活血化瘀 清解通下 增效作用 

分 类 号：R285.5[医药卫生—中药学] Q95-3[医药卫生—中医学]