创伤性休克早期患者血浆TNF和IL-2含量测定及其机制分析  

Study on the actives and their mechanisms of plasma TNF and IL-2 in the early stage of patient suffered from traumatic shock

作　　者：陶占怀[1] 王嘉军[1] 闫保华[1] 剡海宇[1] 刘霞[1] 

机构地区：[1]兰州军区总医院安宁医院,甘肃兰州730070

出　　处：《中国冶金工业医学杂志》2006年第2期133-134,共2页Chinese Medical Journal of Metallurgical industry

摘　　要：目的:探讨创伤性休克早期患者血浆中肿瘤坏死因子(TNF)和白细胞介素2(IL2)含量的意义。方法:采用放射免疫法对21例创伤并休克的患者分别于创伤后0.5、4、24h的血浆TNF和IL2的含量进行测定,并与正常对照组(NC组)36例比较。结果:重度创伤并休克患者血浆TNF明显高于NC组(P<0.05);IL2活性明显低于NC组(P<0.05)。结论:创伤性休克患者早期血浆TNF升高,可能与创伤后早期的炎性反应有关,而IL2活性降低,可能与创伤后巨噬细胞分泌大量的免疫抑制成分有关。Objective： To study the relationship between the TNF and IL-2 in the early stage of the patient suffered from traumatic shock. Methods：The study was carried out by using radio immunoassay method to analyze the plasma levels of TNF and IL 2 at 0.5 h,4 h and 24 h after wound in 21 cases of patients（test group）,and we compared the 21 cases with the 36 cases of normal persons（control group）. Results：The plasma TNF level was higher in test group than in normal control group（P〈0.05）,while the activity of IL-2 was lower in test group than in normal controlgroup（P〈0.05）.Conclusions：The increase of plasma TNF in the early stage of patient suffered from traumatic shock may be related to the early inflammatory reaction after wound,while the decrease of the II. 2 activity may be the reason that macrophages excrete a great amount of immunosuppressant factors.

关 键 词：失血性休克 肿瘤坏死因子 TNF 白细胞介素-2 IL-2 

分 类 号：R602[医药卫生—外科学]