高原红细胞增多症的VEGF变化研究  

Changes of VEGF level in serum of patients with high altitude polycythemia

作　　者：王洪斌[1] 李素芝[1] 姚文新[1] 江成剑[1] 蔡志祥[1] 龙仁玲[1] 

机构地区：[1]西藏军区总医院全军高山病防治研究中心,西藏拉萨850003

出　　处：《西南国防医药》2006年第2期167-168,共2页Medical Journal of National Defending Forces in Southwest China

摘　　要：目的:了解高原红细胞增多症(HAPC)患者的血管内皮生长因子(VEGF)的变化及影响。方法:实验对象被分为8个组:汉族、藏族、男性、女性的HAPC和各自的健康对照组(HC)。ELISA法测定VEGF。结果:HAPC和HC的VEGF值分别是:74.665±6.295、64.628±5.826、68.146±4.536、59.201±6.467、65.273±2.225、58.995±4.523、60.351±6.207、54.629±4.761。VEGF值,HAPC高于HC,汉族高于藏族、男性高于女性(P<0.05或0.01),有显著性和极显著性差异;在HC中,汉族男性与女性相比,无差异(P>0.05)。结论:高原缺氧诱导了VEGF分泌增多,VEGF在HAPC的肺动脉高压、低氧适应调节及并发症中可能发挥了重要作用。Objective： To investigate the changes of vascular endothetial growth fsetor（VEGF） level in serum of patients with high altitude polycythemia（HAPC） and healthy people（HC）. MethOds： The subjects were divided into eight groups hosed on different disease condition（HAFC or HC）, nation（Hart or Tibetan） and sexuality（male or female）. The levels of VEGF were measured with an enzyme - linked immunosorbent assay at high alfitude（abpve sea level 3 658 m）. Results： VEGF levels of subjects with HAPC were higher than those of ones without HAPC, VEGF levels of migrant subjects with HAPC were higher than those of high altitude native subjects with HAPC and VEGF level of healthy Tibetan males was higher than that of healthy Tibetan females（P〈0. 01 to 0. 05）, but there was not difference of VEGF level between Hart males and females. Conclusion： Hypoxia induces devated secretion of VEGF and the changes of VEGF may be related to hypoxic pulmonary hypertension, hypoxic Maptative regulation and complications of HAPC.

关 键 词：高原红细胞增多症 血管内皮生长因子 移居者 世居者 

分 类 号：R555.1[医药卫生—血液循环系统疾病]