伴情感性精神障碍的甲亢及甲低患者神经肽Y水平研究  

Exploration of serum neuropeptide Y concentration in hyperthyroidism and hypothyroidism patients with mental disorder

作　　者：方琳丽[1] 李俊雄[1] 王鲁华[1] 麦芒[1] 关楚文[1] 丘春柳[1] 

机构地区：[1]汕头大学医学院第一附属医院核医学科,广东汕头515041

出　　处：《中国校医》2006年第2期129-131,共3页Chinese Journal of School Doctor

基　　金：汕头市科学技术局2005年重点科技计划项目(2005116)

摘　　要：目的探讨血浆神经肽Y(NPY)水平对伴情感性精神障碍的甲亢及甲低患者的诊断价值。方法①对临床及血清学已确诊的91例甲亢患者和33例甲低患者,在治疗前用放射免疫分析法测定血浆NPY水平,同时进行汉密顿抑郁量表(HAMD)及汉密顿焦虑量表(HAMA)评分。②36名健康体检者作为正常对照组,同时测定血浆NPY水平并进行HAMD、HAMA评分。③对实验组和对照组所有数据进行统计、分析。结果①33例甲低患者NPY水平明显低于正常对照组(P<0.01),HAMD评分明显高于正常对照组(P<0.01),HAMD评分>20分16人,占甲低患者48.48%,其中>35分3人,占9.1%。91例甲亢患者的NPY水平及HAMD评分则明显高于正常对照组(P<0.01),NAMD评分>20分29人,占甲亢患者31.87%,其中>35分1人,占1.1%;HAMA评分明显高于正常对照组(P<0.01),>14分的有43人,占47.25%,其中>29分4人,占4.4%。结论血清NPY水平的测定可以作为早期确定甲状腺疾病伴随的精神症状证据,对是否给予抗精神病药物治疗提供监测指标。Objective To explore the diagnosis value of serum neuropeptide Y （NPY） concentration in hyperthyroidism and hypothyroidism patients with mental disorder. Methods All the studied persons were divided into 3 groups： 91 hyperthyroidism patients in Group 1, 33 hypothyroidism patients in Group 2, and 36 normal persons in Group 3 （control）. The serum NPY levels were measured by RIA mean and the grades were evaluated by HAMD and HAMA. All the data were analysed by t-test. Results The serum level of NPY of hypothyroidism patients was significantly lower than that of normal controls, P 〈 0.01, and the grades of HAMD in hypothyroidism patients were much significantly higher than that in the normal controls,P〈0.01. However, the grades of HAMA had no significant difference between the two groups. The serum levels of NPY, HAMD grades and HAMA grades in hyperthyroidism patients were much significantly higher than those in the normal controls, all P 〈 0.01. Conclusions The level of NPY is the early evidence on depression or anxiety in hyperthyroidism or hypothyroidism patients, and furthermore clinical physicians can decide to administrate anti-mental disorder medicine for them.

关 键 词：神经肽Y 甲状腺机能亢进症 甲状腺机能减退症 精神障碍 

分 类 号：R581[医药卫生—内分泌]