茵栀黄对高胆红素血症新生儿心肌损伤的保护作用  

Cardioprotective Effects of Yinzhihuang Injectionon Newborns with Hyperbilirubinemia

作　　者：刘汉明 

机构地区：[1]河源市源城区埔前人民医院内儿科,广东河源517025

出　　处：《中医药学刊》2006年第4期753-754,共2页Study Journal of Traditional Chinese Medicine

摘　　要：目的:通过观察高胆红素血症新生儿心肌肌钙蛋白I(cTnI)的浓度变化,探讨茵栀黄对高胆红素血症新生儿心肌损伤的保护作用。方法:80例高胆红素血症新生儿随机分为治疗组和对照组。对照组采用常规治疗,包括蓝光照射、补充白蛋白、口服酶诱导剂及纠正酸中毒等处理,治疗组在对照组的基础上,应用茵栀黄注射液治疗。检测治疗前及治疗后7天、14天的cTnI值。结果:与治疗前比较,治疗后7天及14天两组cTnI均有显著降低(P<0.01);治疗组在治疗后7天及14天的cTnI降低幅度均大于对照组(P<0.01);治疗组黄疸消退时间在7天之内的人数明显增多(2χ=11.84,P<0.01)。结论:茵栀黄注射液可缩短高胆血症新生儿黄疸持续时间,降低心肌肌钙蛋白I,对心肌损伤具有显著的保护作用。Objective： To observe the cardioprotective effects of Yinzhihuang Injection on Newborns with Hyperbilirubinemia by comparing change of plasma concentration of cTnI. Methods ： 80 newborns with hyperhilirubinemia were randomly divided into two groups, control group was given routine treatment, and treatment group was receipted Yinzhihuang Injection in the base of control group. The cTnI before treatment and 7d, 14d after treatment was detected. Results： Compared with the value before treatment, the cTnI 7d and 14d after treatment decreased markedly（ P 〈 0.01 ） ; Compared with control group, the cTnI 7d and 14d after treatment in treatment group decreased markedly（ P 〈0.01） ;there were 17 cases in control group and 32 cases in treatment group, whose regression time of jaundice decreased within 7 days, there have a significant difference between the two groups （ χ^2 = 11.84,P 〈0. 01 ）. Conclusion： Yinzhihuang injection have a significant protective effect on myocardial injury in newborns with hyperbilirubinemia.

关 键 词：高胆血症 新生儿 心肌损伤 心肌肌钙蛋白Ⅰ 菌栀黄 

分 类 号：R272.1[医药卫生—中医儿科学]