阻遏诱变剂镉在海洋生物中传递的物质及作用机理的研究（Ⅰ）褐藻酸钠  

STUDY OF THE PROHIBITOR AGAINST TRANSFER OF Cd￣(2+) -MUTAGEN IN MARINE ORGANISMS AND ITS MECHANISM I. SODIUM ALGINATE

作　　者：林光恒[1] 刘明星[1] 孙国琼[1] 

机构地区：[1]中国科学院海洋研究所

出　　处：《癌变．畸变．突变》1996年第1期1-5,共5页Carcinogenesis,Teratogenesis & Mutagenesis

基　　金：国家自然科学基金

摘　　要：镉是海洋中重要的诱变剂，海洋生物体内的镉随食物链流动最后进入人体，本文首次报道了海藻多糖褐藻酸钠不仅能将进入中国对虾体内起致毒作用的镉从体内排至体外，从而降低了肠道对镉的吸收，而且还能在一定程度上降低镉在机体内的遗传毒性，遏制镉的遗传毒性作用。上述结果为化学和生物二方面平行实验所证实。Cadmium is an important mutagcn in marine environmcnt. Our previous work hasrevealed it can be transferred through some marine food chains from lower organisms intahighcr ones,and eventually into human body through consuming Cd(2+)-contaminated marinefoodstuff. Present paper reports a marine alginic polysaccharide,sodium alginate,which ismade from kelp(Lamilaria japonica),has strongcr activity of removing Cd2(+-)mutagenaway from body of prawn Penaeus orientalis,thercfore decreasing the amount of Cd(2+)-ab-sorbed by prawn’s intcstines.Genotoxicitic test with Trad-MCN and chemical analysis withpolarography coincidently show sodium algnate is also a Cd(2+)-mutagen inhibitor which re-duces genotoxicity of Cd(2+)-mutagcn to prawn in a certain extent.

关 键 词：褐藻酸钠 镉 诱变剂 中国对虾 紫露草 

分 类 号：R994.6[医药卫生—毒理学]