抗早孕新药抗孕唑对大鼠的功能畸变作用  

BEHAVICRAL TERATOGENICITY OF CONTRAGESTAZOL ,ANEW EARLY PREGNANCY-TERMINATING AGENT,TESTEDIN RAT

作　　者：应赢[1] 方瑞英[1] 范焱[1] 王知坚 

机构地区：[1]浙江医科大学药学系药理学教研室

出　　处：《癌变．畸变．突变》1996年第1期25-28,共4页Carcinogenesis,Teratogenesis & Mutagenesis

摘　　要：ＳＤ大鼠于妊娠ｄ１５到仔鼠出生后ＰＮ２２连续ｉｍ抗孕唑０．０１和０．２ｍｇ／ｋｇ，另设溶剂对照和甲巯基咪唑阳性对照，对仔鼠作出牙和开眼时间、平面翻正、斜坡转身、听觉惊愕、游泳、开旷场地和Ｙ型水迷宫试验。结果，抗孕唑高剂量组仔鼠体重明显低于活剂组；低剂量组仔鼠长齿时间（１０．６±０．７ｄ）和高剂量组开眼时间（１３．６±０．９ｄ）较溶剂组（１１．４±１．２，１５．３±１．０ｄ）提前，其他指标均无明显改变。阳性对照组多项指标改变显著。因此，抗孕唑在抗早孕阈下剂量时，对仔鼠无功能畸变作用。Groups of pregnant Sprague-Dawley rats were treated with im 0.01 and 0.2mg/kg of contragcstazol(DL111-IT)from gestational day 15 to postnatal day 22,methimazol indrinking water served as positive control.The results showed that there were no marked dif- ferences in surface righting,negative geotaxis,auditory startle,swimming ontogeriy,openfield and water Y-maze between test and vehiele groups. However,the body weight of theoffsprings from rats tred,ted with 0.2mg/kg of contragestazol was significantly reduced.Me-thimazol,a positive control agent,not only caused delay of certain physical development,butalso caused deficits of some behaviors.It was concluded that contragestazol,at dosages belowterminating early pregnancy,did not induce behavioral teratogcnicity of offsprings.

关 键 词：功能畸变 抗孕唑 抗早孕化合物 避孕药 

分 类 号：R979.21[医药卫生—药品]