氟嗪酸的小鼠胚胎毒性及致畸性研究  

EMBRYOTOXICITY AND TERATOGENICITY STUDY OFOFLOXACIN IN NIH MICE

作　　者：朱永平[1] 王敏[1] 倪祖敏[1] 滕素珍 

机构地区：[1]浙江医科大学毒理研究室

出　　处：《癌变．畸变．突变》1996年第1期28-31,共4页Carcinogenesis,Teratogenesis & Mutagenesis

摘　　要：ＮＩＨ小鼠于孕期ｄ６—１５ｐｏ氟嗪酸２１００、７００ｍｇ／ｋｇ，结果高剂量的氟嗪酸使ＮＩＨ孕鼠增重减少，透过胎盘屏障影响胎鼠的生长发育，胎鼠的身长和体重均显著低于溶剂对照组，枕骨和胸骨发育不良率显著增高，颚裂的发生率有增高的趋势。因此临床上应避免给怀孕和哺乳的妇女以及儿童使用该类药物。The embryotoxicity and teratogenicity of ofloxacin in NIH mice were carried out.Ofloxacin was administered at 2100,700mg/kg po on day 6-15 of the gestation, As com-pared to the solvent control,high dosge of ofloxacin(2100 mg/kg ,about 1/3 LD50)was tox-ic to pregnant mice,resulted in reduction of the weight gain during the pregnancy and embry-otoxicity.The body length and weight of survial fetuses in the higher dose group is less andthe percentage of delayed skeletogency is higher than others.No malformation of survial fe-tuses was observed in every group but the percentage of platoschisis in the higher dosegroup tended to be increased.These studies indicated that ofloxacin is embryotoxic but notteratogenic in NIH mice.

关 键 词：氟嗪酸 小鼠 胚胎毒性 致畸性 

分 类 号：R978.19[医药卫生—药品]