维生素E抗B超辐照早孕大鼠的仔鼠神经行为致畸的观察  

Study of Antagonistic Effect of Vitamine E on Neurobehavioral Teratogenesis of Offspring afterUltrasound Irridiation of early Pregnant Rat

作　　者：胡逢来[1] 郝龙江[1] 孙磊[1] 李秀琹 贾建文[1] 苗立英[1] 史旭东[1] 张武[1] 

机构地区：[1]北京医科大学卫生毒理教研室,北京医科大学第三临床医院

出　　处：《中华超声影像学杂志》1996年第2期90-93,共4页Chinese Journal of Ultrasonography

基　　金：国家自然科学基金

摘　　要：本文研究维生素Ｅ抗Ｂ超辐照早孕大鼠的仔鼠神经行为致畸的效应。４０只受孕Ｗｉｓｔａｒ大鼠随机分为４组：Ｂ超加维生素Ｅ（ＶＥ），Ｂ超，ＶＥ组及空白组。观察仔鼠神经行为致畸指标。结果表明．活胎数、体重、体格发育、早期反射及感觉功能、运动和协调功能、学习和记忆等Ｂ超组与空白组间、Ｂ超加ＶＥ组与Ｂ超组间比较有不同程度的显著性差异，提示ＶＥ对２０分钟诊断剂量超声辐射早孕大鼠所致仔鼠神经行为致畸有一定的干预效应。Forty pregnant wistar rats were divided to 4 groups randomly;20 minuted ultrasonud irradiation on 5 th day of gesation+Vit.E,ulurasound irradiation,Vit.E,and control group.Trere were significant difference in the number of alive fetus,body weight,development status,early reflexes,sensation,movement, coordination.learning and memory between ultrasound irradiation+Vit.E and ultrasound inrediation and control group and between ultrasund inradiation group.It is suggested that Vit.E has antagonistic effect on neurobehavioral teratogenesis of rat offspring after ultrasound irradiation of the pregnant rat.

关 键 词：维生素E 超声辐照 神经行为致畸 

分 类 号：R977.25[医药卫生—药品]