海洛因肾病的病理特征——附2例报告及文献复习  

Heroin-associated Nephropathy:A Report of two Cases and Review of the Literature

作　　者：郭文焕[1] 余英豪[1] 郑智勇[1] 季天海[1] 曾玲[1] 刘庆宏[1] 谢福安 

机构地区：[1]南京军区福州总医院病理科,福州350025 [2]南京军区福州肾病中心,福州350025

出　　处：《中国中西医结合肾病杂志》2006年第4期232-234,T0001,共4页Chinese Journal of Integrated Traditional and Western Nephrology

摘　　要：目的:探讨海洛因肾病的临床病理特征及其预后。方法:观察2例海洛因肾病的光镜、电镜和免疫组织化学特征,并复习有关文献。结果:2例均为男性,以肾病综合征入院。光镜和电镜见1例表现为局灶系膜增生性肾小球肾炎,1例为弥漫膜增殖Ⅰ型伴局灶肾小球硬化;免疫组织化学染色见IgM为主的免疫球蛋白沉积。结论:海洛因肾病为长期吸食海洛因导致的肾脏疾病,临床表现以肾病综合征多见,病理形态学、超微结构改变以及免疫组织化学染色无明显特异性,诊断需结合吸毒史并排除其他继发性肾病可能后诊断。Objective： To study the clinical and pathological features and prognosis of heroin - associated nephropathy. Methods.Two cases of heroin- associated nephropathy were investigated by light microscope and electron microscope. Results： Two patients were mate and presented clinically as nephrotic syndrome, Histologically,one ease showed focal mesangial proliferative glomerulonephritis and the other diffuse proliferative glomerulonephritis, Immonohistochemieally, both were positive for IgM predominantly, Conclusion：Heroin-associated nephropathy is caused by chronic heroin abuse with no specific pathological and immunohistochemical features. Nephrotic syndrome is the main clinical manifestation. Its diagnosis should be made based on the history of heroin abuse and exclusion of other secondary nephropathy.

关 键 词：海洛因肾病 病理学 免疫组化 超微结构 

分 类 号：R692[医药卫生—泌尿科学] R595.5[医药卫生—外科学]