脑外伤自体神经干细胞移植后的功能影像学研究  

The Study of Functional Imaging after Autologous Implantation of Neural Progenitor Cells for the Treatment of Traumatic Brain Injury

作　　者：张冬[1] 冯晓源[2] 吴惺[3] 朱剑虹[3] 

机构地区：[1]第三军医大学附属新桥医院放射科,重庆400037 [2]复旦大学附属华山医院放射科,上海200040 [3]复旦大学附属华山医院神经外科,上海200040

出　　处：《临床放射学杂志》2006年第4期301-304,共4页Journal of Clinical Radiology

基　　金：国家重点基础研究发展规划资助项目(2001CB509907)

摘　　要：目的探讨脑外伤自体神经干细胞移植后的脑功能变化。资料与方法对2例脑外伤患者行自体神经干细胞移植,移植前及移植后1个月、3个月,分别行去氧葡萄糖正电子断层扫描(FDGPET)及磁共振功能成像(fMRI)检查。结果移植后3个月,患者神经功能明显改善,FDGPET、fMRI均提示原受损功能区的功能得到恢复。结论自体神经干细胞移植可以改善神经功能,FDGPET及fMRI是分析神经功能改善的重要手段。Objective To explore the function changes after autologous implantation of neural progenitor cells for the treatment of traumatic brain injury. Materials and Methods Neural progenitor cells were autologous implanted at 7 points around the traumatic regions with MKI stereotactic guiding devices for 2 patients of traumatic brain injury, PDG PET and fMKI were performed in 2 patients before and 1,3 month after implantation of neural progenitor cells. Results 3 months after implantation of neural progenitor cells, the tracer uptake in the damaged territory was increased significantly and the activation in fMKI maps was seen in the motor cortex. The functional recovery was markedly obtained in the two patients. Conchusion Implantation of neural progenitor cells can ameliorate the neurological function of injuried regions, PDG PET and fMRI are useful modalities to assess the functional recovery.

关 键 词：脑损伤 磁共振成像 体层摄影术 发射型计算机 

分 类 号：R651[医药卫生—外科学] R445[医药卫生—临床医学]