产妇内源性阿片肽与正常分娩疼痛的关系  

Relationship between endogenous opioid peptides and parturient’s perception of pain during parturition

作　　者：李红[1] 陈丽影[1] 郭建英[1] 

机构地区：[1]泉州市儿童医院妇幼保健院妇产科,福建泉州362000

出　　处：《中国妇幼健康研究》2006年第1期12-14,共3页Chinese Journal of Woman and Child Health Research

摘　　要：目的探讨内源性阿片肽与分娩产痛的关系以及内源性阿片肽之间的关系。方法采用放射免疫测定方法,测定40例足月分娩即刻产妇血浆中三种内源性阿片肽(β-内啡肽6.44±3.93ng/mL、强啡肽Al-1320.30±18.84ng/mL及亮啡肽1.63±2.00ng/mL)的含量。结果血清中强啡肽A1-13与第一产程情绪评分(ES)无显著相关(r=-0.08,P=0.26),而与第二产程ES存在显著的负相关(r=-0.31,P=0.04);血清中β-内啡肽、亮啡肽分别与第一产程(r=0.16,P=0.26;r=-0.04,P=0.8)和第二产程(r=0.08,P=0.57;r=-0.14,P=0.35)ES无显著相关性;血清中β-内啡肽水平与亮啡肽有显著相关性(r=0.371,P=0.04),强啡肽A1-13与β-内啡肽、亮啡肽都无显著相关性(r=0.25,P=0.13;r=0.21,P=0.21)。结论血清强啡肽A1-13升高可削弱第二产程产妇的疼痛感受,β-内啡肽和亮啡肽有协同作用。Objective To study the relationship between the perception of pain during parturition and endogenous opioid peptide （EOP） levels, and interactions of EOPs. Methods Concentrations of plasma EOPs （β-endorphin, dorphin A1-13, leuenkephalin） at deliery were measured immediately by means of radioimmunoassay in 40 term parturients. Results Dorphin A1-13 levels were not correlated significantly with emotional scale （ES）in the first stage of labor （r =-0. 08, P = 0.26）, but correlated significantly with that in the second stage of labor negatively （r =-0. 31, P = 0.04）. Plasma levels of β-endorphin and leuenkephalin were not correlated with ES during either the first or the second stage of labor, respectively. Statistically significant and positive correlation was found between β-endorphin and leuenkephalin （r = 0. 37, P = 0.04）. No significant correlations were found for β-endorphin and leuenkephalin as compared with dolphin A1-13, respectively （ r = 0. 25, P = 0. 13 ; r = 0. 21, P = 0.21 ）. Conclusion The elevated concentrations of dorphin A1-13 in maternal plasma would attenuate the perception of pain in the second stage of labor of the parturients. The analgesic effect of β-endorphin can be synergized with leuenkephalin.

关 键 词：内源性阿片肽 Β-内啡肽 强啡肽A-13 亮啡肽 分娩 疼痛感受 

分 类 号：R714.3[医药卫生—妇产科学]