血清N末端B型钠尿肽原对心力衰竭患者的临床评估  

Value of serum NT-proBNP in the clinical evaluation of heart failure

作　　者：王青[1] 冷峰[1] 李志[1] 崔奕文[1] 

机构地区：[1]大连市中心医院心内科,116033

出　　处：《中国医师进修杂志》2006年第1期18-19,共2页Chinese Journal of Postgraduates of Medicine

摘　　要：目的探讨血清N末端B型钠尿肽原(NT-proBNP)浓度与心功能分级(NYHA)、左室射血分数(LVEF)等临床指标之间的关系,在心功能的评价及其在诊断慢性心力衰竭中的作用。方法选择心力衰竭(简称心衰)患者72例,正常对照30例,采用电化学发光法测定血清NT-proBNP浓度。超声心动测定受试者LVEF。依据美国心脏病协会NYHA分级方法对心衰患者进行心功能分级。心衰诊断以临床医生依据病史、症状、体征、客观检查等作出的综合判断为金标准。结果心衰组NT-proBNP浓度(287.7 pg/ml)显著高于正常对照组(46.1 pg/ml);NYHA分级与NT-proBNP浓度呈显著正相关(r=0.844,P<0.01),LVEF与NT-proBNP浓度呈显著负相关(r=-0.617,P<0.01)。结论NT-proBNP可以客观准确地评价心功能,可作为临床诊断心衰的实验室指标。Objective To investigate the relationships between the concentration of serum NT-proBNP, New York Heart Association（NYHA） classification, left ventricular ejection fraction （LVEF）, and the value of serum NT-proBNP in the evaluation of cardiac function and the diagnosis of chronic heart failure. Methods One hundred and two subjects were selected, including 30 healthy controls and 72 patients with heart failure. The concentration of serum NT-proBNP was determined by an automated electrochemiluminescence immunoassayan Roche Elecsys 2010. LVEF was measured by the modified Simpson＇s equation with echccardiography. The diagnosis of clinical physician was considered to be the golden standard for heart failure. Results The relationships between the concentration of serum NT-proBNP and NYHA, serum NT-proBNP levels （287.7 pg/ml） was significantly higher in heart failure patients（287.7 pg/ml） than that in healthy controls 287.7 pg/ml vs （46.1 pg/ml）, P〈 0.01. NT-proBNP showed positive correlation with NYHA classification （ r = 0. 844, P 〈 0.01）. Conclusion NT-proBNP is a valuable biomarker for the evaluation of cardiac function and the diagnosis of heart failure.

关 键 词：钠尿肽 心力衰竭 心功能分级 

分 类 号：R541.6[医药卫生—心血管疾病]